DIRECT BINDING OF COMPOUNDS TO HUMAN CFTR NBD1: ALLOSTERY AND THE IMPORTANCE OF DOMAIN-DOMAIN INTERACTIONS

被引:0
|
作者
Hudson, Rhea [1 ]
Dawson, Jennifer E. [1 ]
Chong, P. Andrew [1 ]
Vernon, Robert [1 ]
Yang, Zengrong [3 ]
Millen, Linda [4 ]
Thomas, Philip J. [4 ]
Brouillette, Christie [3 ]
Forman-Kay, Julie [1 ,2 ]
机构
[1] Hosp Sick Children, Toronto, ON, Canada
[2] Univ Toronto, Toronto, ON, Canada
[3] Univ Alabama Birmingham, Birmingham, AL USA
[4] Univ Texas Southwestern Med Ctr Dallas, Dallas, TX 75390 USA
关键词
TRANSMEMBRANE CONDUCTANCE REGULATOR;
D O I
暂无
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
S08.1
引用
收藏
页码:141 / 142
页数:2
相关论文
共 50 条
  • [1] DIRECT BINDING OF CFTR MODULATORS TO HUMAN CFTR NBD1
    Hudson, R.
    Chong, P.
    Protasevich, I. I.
    Dawson, J.
    Vernon, R.
    Ney, E.
    Bihler, H.
    An, J. L.
    Kalid, O.
    Sela-Culang, I.
    Mense, M.
    Senderowitz, H.
    Brouillette, C.
    Forman-Kay, J.
    PEDIATRIC PULMONOLOGY, 2012, 47 : 243 - 243
  • [2] Structure of the human CFTR NBD1 domain as a homodimer: Insights and applications
    Atwell, Shane
    Conners, Kris
    Emtage, Spencer
    Gheyi, Tarun
    Lewis, Hal
    Lu, Frances
    Romero, Rich
    Zhao, Xun
    PEDIATRIC PULMONOLOGY, 2007, : 100 - 101
  • [3] Interactions of the Wild-type and ΔF508 CFTR NBD1 domain
    Kanelis, Voula
    Hudson, Rhea P.
    Baker, Jennifer M. R.
    Thibodeau, Patrick H.
    Thomas, Philip J.
    Forman-Kay, Julie D.
    BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 2006, 84 (06): : 1081 - 1081
  • [4] A Novel Activator of ATPase Activity of NBD1 Domain of the CFTR
    Singh, Jay
    Balch, William
    PROTEIN SCIENCE, 2014, 23 : 108 - 108
  • [5] Effect of mutation and a corrector molecule on the nanomechanics of CFTR nucleotide binding domain 1 (NBD1)
    Farkas, B.
    Padanyi, R.
    Tordai, H.
    Kiss, B.
    Grubmueller, H.
    Soya, N.
    Lukacs, G.
    Kellermayer, M.
    Hegedus, T.
    EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2021, 50 (SUPPL 1): : 122 - 122
  • [6] Correctors Rescue CFTR Mutations in Nucleotide-Binding Domain 1 (NBD1) by Modulating Proteostasis
    Lopes-Pacheco, Miqueias
    Sabirzhanova, Inna
    Rapino, Daniele
    Morales, Marcelo M.
    Guggino, William B.
    Cebotaru, Liudmila
    CHEMBIOCHEM, 2016, 17 (06) : 493 - 505
  • [7] ATP occlusion at the first nucleotide binding domain (NBD1) of CFTR is independent of the second (NBD2) and therefore of NBD dimerization
    Aleksandrov, L.
    Aleksandrov, A. A.
    Riordan, J. R.
    PEDIATRIC PULMONOLOGY, 2007, : 205 - 205
  • [8] Integrating the Signals: Implications of CFTR NBD1 Allostery to Cystic Fibrosis
    Jennifer, Dawson E.
    Chong, Andrew
    Vernon, Robert
    Hudson, Rhea
    Farber, Patrick
    Forman-Kay, Julie D.
    BIOPHYSICAL JOURNAL, 2014, 106 (02) : 13A - 13A
  • [9] Domain-domain interactions between intracellular domains of CFTR
    Wang, WL
    He, ZP
    O'Shaughnessy, T
    Reenstra, WW
    BIOPHYSICAL JOURNAL, 2001, 80 (01) : 354A - 354A
  • [10] Regulation of the nbd1/R domain of CFTR by ATP and by protein kinases.
    Cohn, JA
    Borchardt, RA
    Yu, AYR
    Kole, J
    GASTROENTEROLOGY, 1997, 112 (04) : A355 - A355