Palladium-catalyzed phosphine-, copper-free and aerobic Sonogashira coupling in aqueous media

被引：11

作者：

Liu, Chun ^{[1
]}

Bao, Fanying ^{[1
]}

Ni, Qijian ^{[1
]}

机构：

[1] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China

来源：

ARKIVOC | 2011年

基金：

中国国家自然科学基金;

关键词：

Palladium; phosphine-free; aerobic; Sonogashira coupling; aqueous; N-HETEROCYCLIC CARBENES; ARYL BROMIDES; LIGAND-FREE; EFFICIENT CATALYSTS; COMPLEXES; WATER; SUZUKI; TEMPERATURE; ACETYLENES; CHLORIDES;

D O I：

10.3998/ark.5550190.0012.b06

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, highly efficient and phosphine-free protocol for the Sonogashira coupling of aryl iodides with terminal alkynes has been developed using Pd-2(dba)(3) (dba=dibenzylideneacetone) as the catalyst under aqueous, copper-free and aerobic conditions. The coupling of aryl iodides with aromatic terminal alkynes provided good to excellent yields and moderate to good yields were achieved using aliphatic terminal alkynes as one of the coupling partners. Aqueous ethanol as solvent is economical and environmentally benign in accordance with the concept of green chemistry.

引用

页码：60 / 68

页数：9

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