Molecularly Imprinted Solid Phase Extraction Strategy for Quinic Acid

被引:6
|
作者
Megahed, Sarah H. [1 ]
Abdel-Halim, Mohammad [1 ]
Hefnawy, Amr [2 ]
Handoussa, Heba [3 ]
Mizaikoff, Boris [4 ,5 ]
El Gohary, Nesrine A. [1 ]
机构
[1] German Univ Cairo, Fac Pharm & Biotechnol, Dept Pharmaceut Chem, Cairo 11835, Egypt
[2] Univ Texas Austin, Coll Pharm, Div Mol Pharmaceut & Drug Delivery, Austin, TX 78712 USA
[3] German Univ Cairo, Fac Pharm & Biotechnol, Pharmaceut Biol Dept, Cairo 11835, Egypt
[4] Ulm Univ, Inst Analyt & Bioanalyt Chem, D-89081 Ulm, Germany
[5] Hahn Schickard, D-89077 Ulm, Germany
关键词
computational modelling; molecularly imprinted polymers; solid-phase extraction; quinic acid; Coffea arabica; SELECTIVE EXTRACTION; CAFFEIC ACID; COMPUTATIONAL DESIGN; D-(-)-QUINIC ACID; CHLOROGENIC ACID; BISPHENOL-A; POLYMER; SENSORS; NANOPARTICLES; ANTIOXIDANT;
D O I
10.3390/polym14163339
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Quinic acid (QA) and its ester conjugates have been subjected to in-depth scientific investigations for their antioxidant properties. In this study, molecularly imprinted polymers (MIPs) were used for selective extraction of quinic acid (QA) from coffee bean extract. Computational modelling was performed to optimize the process of MIP preparation. Three different functional monomers (allylamine, methacrylic acid (MAA) and 4-vinylpyridine (4-VP)) were tested for imprinting. The ratio of each monomer to template chosen was based on the optimum ratio obtained from computational studies. Equilibrium rebinding studies were conducted and MIP C, which was prepared using 4-VP as functional monomer with template to monomer ratio of 1:5, showed better binding performance than the other prepared MIPs. Accordingly, MIP C was chosen to be applied for selective separation of QA using solid-phase extraction. The selectivity of MIP C towards QA was tested versus its analogues found in coffee (caffeic acid and chlorogenic acid). Molecularly imprinted solid-phase extraction (MISPE) using MIP C as sorbent was then applied for selective extraction of QA from aqueous coffee extract. The applied MISPE was able to retrieve 81.918 +/- 3.027% of QA with a significant reduction in the amount of other components in the extract.
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页数:24
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