Using stem cells to study and possibly treat type 1 diabetes

被引：20
|
作者：
Melton, D. A. [1 ]
机构：
[1] Harvard Univ, Howard Hughes Med Inst, Harvard Stem Cell Inst, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA
来源：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2011年 / 366卷 / 1575期
关键词：
pancreas; diabetes; stem cells; juvenile diabetes; type; 1; chemical screening; BETA-CELLS; NOD MICE; IN-VIVO; DIFFERENTIATION; MODELS; MOUSE;
D O I：
10.1098/rstb.2011.0019
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Stem cells with the potential to form many different cell types are actively studied for their possible use in cell replacement therapies for several diseases. In addition, the differentiated derivatives of stem cells are being used as reagents to test for drugs that slow or correct disease phenotypes found in several degenerative diseases. This paper explores these approaches in the context of type 1 or juvenile diabetes, pointing to recent successes as well as the technical and theoretical challenges that lie ahead in the path to new treatments and cures.
引用
收藏
页码：2307 / 2311
页数：5
相关论文
共 50 条
  • [41] Tissue engineering approaches and generation of insulin-producing cells to treat type 1 diabetes
    Khazaei, Mozafar
    Khazaei, Fatemeh
    Niromand, Elham
    Ghanbari, Elham
    JOURNAL OF DRUG TARGETING, 2023, 31 (01) : 14 - 31
  • [42] Transplantation of co - aggregates of dissociated islet cells and sertoli cells to treat type 1 diabetes in mice.
    Takemoto, N.
    Liu, X.
    Takii, K.
    Iwata, H.
    JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2012, 6 : 121 - 121
  • [43] Applicability of Adipose-Derived Stem Cells in Type 1 Diabetes Mellitus
    Lin, Hui-Ping
    Chan, Tzu-Min
    Fu, Ru-Huei
    Chuu, Chih-Pin
    Chiu, Shao-Chih
    Tseng, Yu-Hsiung
    Liu, Shih-Ping
    Lai, Kuang-Chi
    Shih, Mu-Chin
    Lin, Zung-Sheng
    Chen, Hsin-Shui
    Yeh, Da-Chuan
    Lin, Shinn-Zong
    CELL TRANSPLANTATION, 2015, 24 (03) : 521 - 532
  • [44] Human cord blood stem cells and the journey to a cure for type 1 diabetes
    Zhao, Yong
    Mazzone, Theodore
    AUTOIMMUNITY REVIEWS, 2010, 10 (02) : 103 - 107
  • [45] Adult stem or progenitor cells in treatment for type 1 diabetes: current progress
    Liao, Yu Huan T.
    Verchere, C. Bruce
    Warnock, Garth L.
    CANADIAN JOURNAL OF SURGERY, 2007, 50 (02) : 137 - 142
  • [46] Stem cells: An emerging novel therapeutic for type-1 diabetes mellitus
    Thakkar, Umang G.
    Vanikar, Aruna V.
    Trivedi, Hargovind L.
    DIABETES RESEARCH AND CLINICAL PRACTICE, 2017, 130 : 130 - 132
  • [47] Stem Cell-Derived Beta Cells for Treatment of Type 1 Diabetes?
    Goland, Robin
    Egli, Dieter
    EBIOMEDICINE, 2014, 1 (2-3): : 93 - 94
  • [48] ADULT STEM CELLS COULD HOLD KEY TO TYPE 1 DIABETES CURE
    不详
    STEM CELLS TRANSLATIONAL MEDICINE, 2013, 2 (07) : XII - XII
  • [49] CLINICAL TRIALS TEST ADULT STEM CELLS IN SLOWING TYPE 1 DIABETES
    不详
    STEM CELLS TRANSLATIONAL MEDICINE, 2012, 1 (07) : IX - IX
  • [50] Immunomodulation by mesenchymal stem cells - A potential therapeutic strategy for type 1 diabetes
    Abdi, Reza
    Fiorina, Paolo
    Adra, Chaker N.
    Atkinson, Mark
    Sayegh, Mohamed H.
    DIABETES, 2008, 57 (07) : 1759 - 1767
12345