Aberrant expression of MCM2 and Ki-67 are associated with endometrial carcinoma and its survival rate

Objective: Endometrial carcinoma (EC) is one of the most common gynecologic malignancies. Minichromosome maintenance-2 (MCM2) and Ki-67 are both expressed during whole cell cycle to regulate proliferation and they have been proposed as potential prognostic markers in various tumors. In present study, we aim to examine the relationship between endometrial carcinoma and aberrant expression of MCM2 and Ki67. Methods: The expression of MCM2 and Ki-67 in normal endometrium tissues, atypical hyperplasia of endometrium (EAH) tissues and endometrioid adenocarcinoma (EAC) tissues were detected by immunohistochemical staining and statistically analyzed subsequently. Results: The positive expression rate of MCM2 and Ki67 both showed statistical difference among normal tissues, EAH tissues, and EAC tissues. For clinical pathological characteristics, the positive expression of MCM2 was related to the histopathologic grade and depth of stromal invasion, while the positive expression of Ki67 was related to the lymph node metastasis. There was a positive correlation between MCM2 and Ki-67 protein in EA tissues. Moreover, the 3-years survival rate in MCM2 high expression group was significantly lower than that in the low expression group. Conclusions: MCM2 and Ki-67 expression are significantly higher in EC tissues and their expressions are positively correlated. Expression of MCM2 affects the 3-year survival rate in patients with EAC, indicating MCM2 can be regarded as a prognosticator in EAC diagnosis.