The effect of caffeic acid phenethyl ester on ischemia-reperfusion injury in comparison with α-tocopherol in rat kidneys

被引：114
|
作者：
Irmak, MK
Koltuksuz, U [1 ]
Kutlu, NO
Yagmurca, M
Özyurt, H
Karaman, A
Akyol, Ö
机构：
[1] Inonu Univ, Fac Med, Dept Pediat Surg, Malatya, Turkey
[2] Inonu Univ, Fac Med, Dept Biochem, Malatya, Turkey
[3] Inonu Univ, Fac Med, Dept Pediat, Malatya, Turkey
[4] Inonu Univ, Fac Med, Dept Histol & Embryol, Malatya, Turkey
来源：
UROLOGICAL RESEARCH | 2001年 / 29卷 / 03期
关键词：
reperfusion injury; kidney; caffeic acid phenethyl ester; alpha-tocopherol;
D O I：
10.1007/s002400100185
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Oxygen-derived free radicals have been implicated in the pathogenesis of renal injury after ischemia-reperfusion. Caffeic acid phenethyl ester (CAPE), an active component of propolis extract, exhibits antioxidant and anti-inflammatory properties. To determine whether CAPE offers any advantage over alpha -tocopherol, we compared their effects on an in vivo model of renal ischemia-reperfusion injury in rats. CAFE at 10 mu mol/kg or alpha -tocopherol at 10 mg/kg was administered intraperitoneally before reperfusion. Acute administration of CAFE suppressed ischemia-reperfusion induced renal lipid peroxidation and tissue injury more than alpha -tocopherol. CAFE may therefore offer a therapeutic advantage in acute injury settings.
引用
收藏
页码：190 / 193
页数：4
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