Frontotemporal dementia and COVID-19: Hypothesis generation and roadmap for future research

被引：5

作者：

Ng, Kok Pin ^{[1
,2
,3
]}

Chiew, Hui Jin ^{[1
]}

Hameed, Shahul ^{[1
,2
,3
]}

Ting, Simon Kang Seng ^{[1
,2
,3
]}

Ng, Adeline ^{[1
,2
,3
]}

Soo, See Ann ^{[1
]}

Wong, Benjamin Y. X. ^{[1
]}

Lim, Levinia ^{[1
]}

Yong, Alisa C. W. ^{[1
]}

Mok, Vincent C. T. ^{[4
]}

Rosa-Neto, Pedro ^{[5
]}

Dominguez, Jacqueline ^{[6
]}

Kim, SangYun ^{[7
,8
]}

Hsiung, G. Y. Robin ^{[9
]}

Ikeda, Manabu ^{[10
]}

Miller, Bruce L. ^{[11
]}

Gauthier, Serge ^{[5
]}

Kandiah, Nagaendran ^{[1
,2
,3
]}

机构：

[1] Natl Neurosci Inst, Dept Neurol, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore

[2] Duke NUS Med Sch, Singapore, Singapore

[3] Nanyang Technol Univ, Imperial Coll London, Lee Kong Chian Sch Med, Singapore, Singapore

[4] Chinese Univ Hong Kong, Prince Wales Hosp, Fac Med,Dept Med & Therapeut,Shatin, Gerald Choa Neurosci Ctr,Lui Che Woo Inst Innovat, Hong Kong, Peoples R China

[5] McGill Univ, Douglas Res Inst,Res Ctr Studies Aging,Alzheimers, Ctr Integre Univ Sante & Serv Sociaux CIUSSS Oues, Dept Neurol & Neurosurg,Psychiat & Pharmacol & Th, Montreal, PQ, Canada

[6] St Lukes Med Ctr, Inst Neurosci, Manila, Philippines

[7] Seoul Natl Univ, Coll Med, Dept Neurol, Seongnam Si, South Korea

[8] Seoul Natl Univ, Bundang Hosp, Clin Neurosci Ctr, Seongnam Si, South Korea

[9] Univ British Columbia, Dept Med, Vancouver, BC, Canada

[10] Osaka Univ, Grad Sch Med, Dept Psychiat, Osaka, Japan

[11] Univ Calif San Francisco, Memory & Aging Ctr, Dept Neurol, San Francisco, CA USA

来源：

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS | 2020年 / 6卷 / 01期

关键词：

COVID-19; frontotemporal dementia; research roadmap; BEHAVIORAL-VARIANT; NETWORK CONNECTIVITY; DIAGNOSIS; BURDEN;

D O I：

10.1002/trc2.12085

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The COVID-19 pandemic has caused tremendous suffering for patients with dementia and their caregivers. We conducted a survey to study the impact of the pandemic on patients with mild frontotemporal dementia (FTD). Our preliminary findings demonstrate that patients with FTD have significant worsening in behavior and social cognition, as well as suffer greater negative consequences from disruption to healthcare services compared to patients with AD. The reduced ability to cope with sudden changes to social environments places patients with FTD at increased vulnerability to COVID-19 infection as well as to poorer clinical and social outcomes. Caregivers of FTD patients also demonstrate high burden during crisis situations. A proportion of patients with FTD benefitted from use of web-based interactive platforms. In this article, we outline the priority areas for research as well as a roadmap for future collaborative research to ensure greatest benefit for patients with FTD and their caregivers.

引用

页数：9

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