The influence of fullerenol on antioxidative enzyme activity in irradiated human erythroleukemic cell line (K562)

被引：0

作者：

Bogdanovic, Visnja ^{[1
]}

Stankov, Karmen ^{[2
]}

Nikolic, Aleksandra ^{[3
]}

Icevic, Ivana ^{[4
]}

Solajic, Slavica ^{[1
]}

Bogdanovic, Gordana ^{[1
]}

Dordevic, Aleksandar ^{[4
]}

机构：

[1] Inst Oncol, Sremska Kamenica, Serbia

[2] Fac Med, Dept Beiochem, Novi Sad, Serbia

[3] Inst Biol Res Sinisa Stankov, Belgrade, Serbia

[4] Univ Novi Sad, Fac Sci, Dept Chem, Novi Sad, Serbia

来源：

HEMIJSKA INDUSTRIJA | 2007年 / 61卷 / 03期

关键词：

x-irradiation; cell culture; antioxidative enzymes;

D O I：

10.2298/HEMIND0703164B

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Cell culture K562 samples were treated with fullerenol (C-60(OH)(24)) at a concentration of 10 nmol/mL and thereafter irradiated with X-rays (24Gy). The activity of gamma-glutarnyltransfrease (gamma-GT), total superoxide-dismutase (SOD) and glutathion-peroxidase (GSH-Px) was determined 1, 24 and 48 hours after irradiation. Irradiation induces an increase in the activity of all the investigated enzymes. Fullerenol in the applied dose decreased the gamma-GT activity 24 and 48 h after irradiation. The total SOD activity is increased in both pretreated groups except in the iradiated group at the 48(th) hour. Treatment with fullerenol before irradiation increased GSH-Px activity in irradiated groups and decreased it in the control groups.

引用

页码：164 / 166

页数：3

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