New aspects of the Warburg effect in cancer cell biology

被引：249

作者：

Bensinger, Steven J. ^{[1
,2
,3
]}

Christofk, Heather R. ^{[2
,3
,4
,5
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Inst Mol Med, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

[5] Univ Calif Los Angeles, Broad Stem Cell Res Ctr, Los Angeles, CA 90095 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2012年 / 23卷 / 04期

关键词：

Aerobic glycolysis; Cancer; Metabolism; Warburg effect; Mitochondria; PYRUVATE-KINASE M2; TUMOR METABOLISM; MITOCHONDRIAL-DNA; TYROSINE PHOSPHORYLATION; ALLOSTERIC REGULATION; AEROBIC GLYCOLYSIS; SIGNALING PATHWAY; ENERGY-METABOLISM; GENE-EXPRESSION; IDH2; MUTATIONS;

D O I：

10.1016/j.semcdb.2012.02.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Altered cellular metabolism is a defining feature of cancer [1]. The best studied metabolic phenotype of cancer is aerobic glycloysis - also known as the Warburg effect - characterized by increased metabolism of glucose to lactate in the presence of sufficient oxygen. Interest in the Warburg effect has escalated in recent years due to the proven utility of FDG-PET for imaging tumors in cancer patients and growing evidence that mutations in oncogenes and tumor suppressor genes directly impact metabolism. The goals of this review are to provide an organized snapshot of the current understanding of regulatory mechanisms important for Warburg effect and its role in tumor biology. Since several reviews have covered aspects of this topic in recent years, we focus on newest contributions to the field and reference other reviews where appropriate. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：352 / 361

页数：10

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