Botulinum toxin injections do not improve freezing of gait in Parkinson disease

被引：34
|
作者：
Wieler, M
Camicioli, R
Jones, A
Martin, WRW
机构：
[1] Univ Alberta, Dept Med Neurol, Edmonton, AB, Canada
[2] Univ Alberta, Dept Phys Therapy & Publ Hlth Sci, Edmonton, AB, Canada
来源：
NEUROLOGY | 2005年 / 65卷 / 04期
关键词：
D O I：
10.1212/01.wnl.0000172930.63669.c8
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Freezing of gait ( FOG) is common in patients with Parkinson disease (PD) and responds poorly to medical treatment. Botulinum toxin A (BTX-A) injections into calf muscles decreased FOG in previous open-label studies. The authors conducted a randomized double-blind placebo-controlled crossover study of BTX-A vs placebo in 12 subjects with PD and FOG. No significant improvement with BTX-A was found using subjective and objective measures.
引用
收藏
页码：626 / 628
页数：3
相关论文
共 50 条
  • [41] Amantadine for Freezing of Gait in Patients With Parkinson Disease
    Malkani, Roneil
    Zadikoff, Cindy
    Melen, Onur
    Videnovic, Aleksandar
    Borushko, Emily
    Simuni, Tanya
    CLINICAL NEUROPHARMACOLOGY, 2012, 35 (06) : 266 - 268
  • [42] Bupropion on freezing of gait in Parkinson's disease
    Kim, W. C.
    Oh, S. H.
    Kim, H. S.
    Kim, O. J.
    MOVEMENT DISORDERS, 2011, 26 : S106 - S107
  • [43] Freezing of Gait and Falls in Parkinson's Disease
    Okuma, Yasuyuki
    JOURNAL OF PARKINSONS DISEASE, 2014, 4 (02) : 255 - 260
  • [44] Freezing and gait disorders in Parkinson's disease
    Goncalves, Giovanna
    Pereira, Joao
    REVISTA MEDICA DE CHILE, 2013, 141 (06) : 758 - 764
  • [45] Freezing of gait in Chinese patients with Parkinson Disease
    Ou, Ruwei
    Guo, Xiaoyan
    Song, Wei
    Cao, Bei
    Yang, Jing
    Wei, Qianqian
    Shao, Na
    Shang, Huifang
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2014, 345 (1-2) : 56 - 60
  • [46] Effect of multisite botulinum toxin injections on gait quality in adults with cerebral palsy
    Marchiori, Claire
    Roche, Nicolas
    Vuillerme, Nicolas
    Zory, Raphael
    Pradon, Didier
    DISABILITY AND REHABILITATION, 2014, 36 (23) : 1971 - 1974
  • [47] The effect of injecting botulinum toxin type A into the calf muscles on freezing of gait in Parkinson's disease: A double blind placebo-controlled pilot study
    Gurevich, Tanya
    Peretz, Chava
    Moore, Orna
    Weizmann, Nina
    Giladi, Nir
    MOVEMENT DISORDERS, 2007, 22 (06) : 880 - 883
  • [48] Boostering motor imagery processing to improve gait in patients with Parkinson's disease and freezing of gait: a preliminary study
    Mezzarobba, S.
    Ravizzotti, E.
    Bernardis, P.
    Putzolu, M.
    Cosentino, C.
    Botta, A.
    Bonassi, G.
    Marchese, R.
    Avanzino, L.
    Pelosin, E.
    MOVEMENT DISORDERS, 2022, 37 : S543 - S543
  • [49] Pretarsal injections of botulinum toxin improve blepharospasm in previously unresponsive patients
    Albanese, A
    Bentivoglio, AR
    Colosimo, C
    Galardi, G
    Maderna, L
    Tonali, P
    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1996, 60 (06): : 693 - 694
  • [50] Botulinum toxin A for drooling in Parkinson's disease: A pilot study to compare submandibular to parotid gland injections
    Kalf, Johanna G.
    Smit, Anne M.
    Bloem, Bastiaan R.
    Zwarts, Machiel J.
    Mulleners, Wim M.
    Munneke, Marten
    PARKINSONISM & RELATED DISORDERS, 2007, 13 (08) : 532 - 534
12345