Small molecule inhibitors of IRAK4

被引:0
|
作者
Bryan, Marian [1 ]
机构
[1] Genentech Inc, San Francisco, CA USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
20-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [21] Delayed Presentation of IRAK4 Deficiency
    Sacta, Maria A.
    Lee, Juhee
    JOURNAL OF CLINICAL IMMUNOLOGY, 2024, 44 (05)
  • [22] Identification and in vivo evaluation of novel IRAK4 inhibitors in murine models of lupus
    Hynes, John
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 256
  • [23] A small molecule potent IRAK4 inhibitor abrogates lipopolysaccharide-induced macrophage inflammation in-vitro and in-vivo
    Choudhary, Saynaz A.
    Patra, Debarun
    Sinha, Archana
    Mazumder, Sayani
    Pant, Rajat
    Chouhan, Raju
    Jha, Anupam Nath
    Prusty, Biswa Mohan
    Manna, Debasis
    Das, Sajal K.
    Tikoo, Kulbhushan
    Pal, Durba
    Dasgupta, Suman
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2023, 944
  • [24] Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors
    Hanisak, Jennifer
    Seganish, W. Michael
    McElroy, William T.
    Tang, Haiquin
    Zhang, Rui
    Tsui, Hon-Chung
    Fischmann, Theirry
    Tulshian, Deen
    Tata, James
    Sondey, Christopher
    Devito, Kristine
    Fossetta, James
    Garlisi, Charles G.
    Lundell, Daniel
    Niu, Xiaoda
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (17) : 4250 - 4255
  • [25] Identification and optimization of indolo[2,3-c]quinoline inhibitors of IRAK4
    Tumey, L. Nathan
    Boschelli, Diane H.
    Bhagirath, Niala
    Shim, Jaechul
    Murphy, Elizabeth A.
    Goodwin, Deborah
    Bennett, Eric M.
    Wang, Mengmeng
    Lin, Lih-Ling
    Press, Barry
    Shen, Marina
    Frisbie, Richard K.
    Morgan, Paul
    Mohan, Shashi
    Shin, Julia
    Rao, Vikram R.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (09) : 2066 - 2072
  • [26] Discovery of First-in-Class IRAK4 Scaffolding Inhibitors for the Treatment of Inflammatory Disorders
    Byth, Kate
    Morgan, Rodney
    Michelys, Pierre
    Demock, Kellie
    Kannan, Geetha
    Chen, Qing
    Sanchez, Brian
    Lu, Xiaokang
    Telling, Alissa
    Lesch, Chuck
    Yu, Carmen
    Bradley, Sarah
    Andresen, Brian
    Hassanien, Sherif
    Taylor, Clarke
    Hou, Zhilin
    Borrelli, Ken
    Gardberg, Anna
    Munschy, Erika
    Schwaid, Adam
    Opipari, Anthony
    Pan, Shifeng
    Franchi, Luigi
    ARTHRITIS & RHEUMATOLOGY, 2023, 75 : 4970 - 4971
  • [27] IRAK4 degrader to take on innate immunity
    Mullard, Asher
    NATURE BIOTECHNOLOGY, 2020, 38 (11) : 1221 - 1223
  • [28] IRAK4 Deficiency Promotes Cardiac Remodeling
    Yuan, Yuan
    Tang, Qizhu
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2014, 64 (16) : C13 - C13
  • [29] IRAK4 and its Ethnic Protein Variants
    Yeyeodu, Susan
    Laurie, Nikia
    Kimbro, Sean K.
    PROTEIN SCIENCE, 2023, 32 (12)
  • [30] Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839
    Bothe, Ulrich
    Guenther, Judith
    Nubbemeyer, Reinhard
    Siebeneicher, Holger
    Ring, Sven
    Boemer, Ulf
    Peters, Michaele
    Rausch, Alexandra
    Denner, Karsten
    Himmel, Herbert
    Sutter, Andreas
    Terebesi, Ildiko
    Lange, Martin
    Wengner, Antje M.
    Guimond, Nicolas
    Thaler, Tobias
    Platzek, Johannes
    Eberspaecher, Uwe
    Schaefer, Martina
    Steuber, Holger
    Zollner, Thomas M.
    Steinmeyer, Andreas
    Schmidt, Nicole
    JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (02) : 1225 - 1242