The aim of this study was to determine whether experimentally-induced endotoxaemia induced elevations in plasma cardiac troponin I (cTnI) concentrations in horses and how this might affect the incidence of cardiac arrhythmias. Eight Standardbred horses received an intravenous continuous rate infusion of endotoxin (total dose 500 ng/kg) for 6 h while being monitored using electrocardiography (ECG). Blood samples were collected before the start of the endotoxin infusion, every 60 min during the infusion, then 1, 2, 3, 8, 10 and 24 h post-infusion, and analysed for cTnI concentrations. One horse was excluded from the study owing to a high initial cTnI concentration. Endotoxin infusion induced an increase in cTnI concentrations in all horses, reaching mean peak concentration of 0.135 +/- 0.094 mu g/L by 1 h post-infusion. The cTnI concentrations then decreased and were no longer significantly different from pre-infusion concentrations at 6, 10 and 24 h post-infusion. The number of ventricular events was generally low during the infusion period, but increased during the first 3 h post-infusion in 6/7 horses. In conclusion, elevated cTnI concentrations could be detected early after an endotoxaemic insult using an ultrasensitive cTnI assay, with peak cTnI concentrations preceding the occurrence of ventricular events on ECG. (C) 2011 Elsevier Ltd. All rights reserved.
机构:
Univ Estadual Paulista Unesp, Programa Pos Grad Med Vet, FMVZ, BR-18618000 Botucatu, SP, BrazilUniv Estadual Paulista Unesp, Programa Pos Grad Med Vet, FMVZ, BR-18618000 Botucatu, SP, Brazil
Yonezawa, Leticia Andreza
Machado, Luciana Pereira
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Univ Fed Piaui UFPI, Pi, BrazilUniv Estadual Paulista Unesp, Programa Pos Grad Med Vet, FMVZ, BR-18618000 Botucatu, SP, Brazil
Machado, Luciana Pereira
da Silveira, Veridiana Fernandes
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UFRB, Cruz Das Almas, BA, BrazilUniv Estadual Paulista Unesp, Programa Pos Grad Med Vet, FMVZ, BR-18618000 Botucatu, SP, Brazil
da Silveira, Veridiana Fernandes
Watanabe, Marcos Jun
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UNESP, FMVZ, Dept Cirurgia & Anestesiol Vet, Botucatu, SP, BrazilUniv Estadual Paulista Unesp, Programa Pos Grad Med Vet, FMVZ, BR-18618000 Botucatu, SP, Brazil
Watanabe, Marcos Jun
Saito, Mere Erika
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UDESC, Dept Vet Med, Lages, SC, BrazilUniv Estadual Paulista Unesp, Programa Pos Grad Med Vet, FMVZ, BR-18618000 Botucatu, SP, Brazil
Saito, Mere Erika
Kitamura, Sandra Satiko
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Univ Anhembi Morumbi, Sao Paulo, BrazilUniv Estadual Paulista Unesp, Programa Pos Grad Med Vet, FMVZ, BR-18618000 Botucatu, SP, Brazil
Kitamura, Sandra Satiko
Kohayagawa, Aguemi
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UNESP, FMVZ, Dept Clin Vet, Botucatu, SP, BrazilUniv Estadual Paulista Unesp, Programa Pos Grad Med Vet, FMVZ, BR-18618000 Botucatu, SP, Brazil
机构:
Michigan State Univ, Coll Vet Med, Dept Large Anim Clin Sci, 736 Wilson Rd Room D202, E Lansing, MI 48824 USA
Newcastle Equine Ctr, POB 123, Broadmeadows, NSW 2292, AustraliaMichigan State Univ, Coll Vet Med, Dept Large Anim Clin Sci, 736 Wilson Rd Room D202, E Lansing, MI 48824 USA
Gallant, L. R.
Jacob, S., I
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Michigan State Univ, Coll Vet Med, Dept Large Anim Clin Sci, 736 Wilson Rd Room D202, E Lansing, MI 48824 USAMichigan State Univ, Coll Vet Med, Dept Large Anim Clin Sci, 736 Wilson Rd Room D202, E Lansing, MI 48824 USA
Jacob, S., I
Tadros, E. M.
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Michigan State Univ, Coll Vet Med, Dept Large Anim Clin Sci, 736 Wilson Rd Room D202, E Lansing, MI 48824 USAMichigan State Univ, Coll Vet Med, Dept Large Anim Clin Sci, 736 Wilson Rd Room D202, E Lansing, MI 48824 USA
Tadros, E. M.
Woodrow, J. S.
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Univ Tennessee, Coll Vet Med, Dept Large Anim Clin Sci, 2407 River Dr, Knoxville, TN 37996 USAMichigan State Univ, Coll Vet Med, Dept Large Anim Clin Sci, 736 Wilson Rd Room D202, E Lansing, MI 48824 USA
Woodrow, J. S.
Hines, M. T.
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Univ Tennessee, Coll Vet Med, Dept Large Anim Clin Sci, 2407 River Dr, Knoxville, TN 37996 USAMichigan State Univ, Coll Vet Med, Dept Large Anim Clin Sci, 736 Wilson Rd Room D202, E Lansing, MI 48824 USA
Hines, M. T.
Ewart, S. L.
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Michigan State Univ, Coll Vet Med, Dept Large Anim Clin Sci, 736 Wilson Rd Room D202, E Lansing, MI 48824 USAMichigan State Univ, Coll Vet Med, Dept Large Anim Clin Sci, 736 Wilson Rd Room D202, E Lansing, MI 48824 USA
Ewart, S. L.
Schott, H. C., II
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Michigan State Univ, Coll Vet Med, Dept Large Anim Clin Sci, 736 Wilson Rd Room D202, E Lansing, MI 48824 USAMichigan State Univ, Coll Vet Med, Dept Large Anim Clin Sci, 736 Wilson Rd Room D202, E Lansing, MI 48824 USA
机构:
Univ Politecn Valencia, Nanophoton Technol Ctr, Cami de Vera S-N, E-46022 Valencia, SpainUniv Politecn Valencia, Nanophoton Technol Ctr, Cami de Vera S-N, E-46022 Valencia, Spain
Sabek, Jad
Martinez-Perez, Paula
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Univ Politecn Valencia, Nanophoton Technol Ctr, Cami de Vera S-N, E-46022 Valencia, SpainUniv Politecn Valencia, Nanophoton Technol Ctr, Cami de Vera S-N, E-46022 Valencia, Spain
Martinez-Perez, Paula
Garcia-Ruperez, Jaime
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Univ Politecn Valencia, Nanophoton Technol Ctr, Cami de Vera S-N, E-46022 Valencia, SpainUniv Politecn Valencia, Nanophoton Technol Ctr, Cami de Vera S-N, E-46022 Valencia, Spain