Cardiac troponin I and the occurrence of cardiac arrhythmias in horses with experimentally induced endotoxaemia

被引:34
|
作者
Nostell, Katarina [1 ]
Brojer, Johan [1 ]
Hoglund, Katja [2 ]
Edner, Anna [1 ]
Haggstrom, Jens [1 ]
机构
[1] Swedish Univ Agr Sci, Dept Clin Sci, S-75007 Uppsala, Sweden
[2] Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, S-75007 Uppsala, Sweden
来源
VETERINARY JOURNAL | 2012年 / 192卷 / 02期
关键词
Endotoxaemia; Horse; Cardiac; cTnI; Arrhythmia; ESCHERICHIA-COLI; VENTRICULAR DYSFUNCTION; MYOCARDIAL-INFARCTION; SEPTIC SHOCK; DEPRESSION; MARKERS; SEPSIS; INJURY;
D O I
10.1016/j.tvjl.2011.05.013
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
The aim of this study was to determine whether experimentally-induced endotoxaemia induced elevations in plasma cardiac troponin I (cTnI) concentrations in horses and how this might affect the incidence of cardiac arrhythmias. Eight Standardbred horses received an intravenous continuous rate infusion of endotoxin (total dose 500 ng/kg) for 6 h while being monitored using electrocardiography (ECG). Blood samples were collected before the start of the endotoxin infusion, every 60 min during the infusion, then 1, 2, 3, 8, 10 and 24 h post-infusion, and analysed for cTnI concentrations. One horse was excluded from the study owing to a high initial cTnI concentration. Endotoxin infusion induced an increase in cTnI concentrations in all horses, reaching mean peak concentration of 0.135 +/- 0.094 mu g/L by 1 h post-infusion. The cTnI concentrations then decreased and were no longer significantly different from pre-infusion concentrations at 6, 10 and 24 h post-infusion. The number of ventricular events was generally low during the infusion period, but increased during the first 3 h post-infusion in 6/7 horses. In conclusion, elevated cTnI concentrations could be detected early after an endotoxaemic insult using an ultrasensitive cTnI assay, with peak cTnI concentrations preceding the occurrence of ventricular events on ECG. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码:171 / 175
页数:5
相关论文
共 50 条
  • [41] Interaction of levosimendan with cardiac troponin C in the presence of cardiac troponin I peptides
    Sorsa, T
    Pollesello, P
    Permi, P
    Drakenberg, T
    Kilpeläinen, I
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2003, 35 (09) : 1055 - 1061
  • [42] Magnesium - Calcium exchange in cardiac troponin C bound to cardiac troponin I
    Finley, NL
    Rosevear, PR
    BIOPHYSICAL JOURNAL, 2000, 78 (01) : 364A - 364A
  • [43] Atrial fibrillation-induced cardiac troponin I release
    Parwani, Abdul Shokor
    Boldt, Leif-Hendrik
    Huemer, Martin
    Wutzler, Alexander
    Blaschke, Daniela
    Rolf, Sascha
    Moeckel, Martin
    Haverkamp, Wilhelm
    INTERNATIONAL JOURNAL OF CARDIOLOGY, 2013, 168 (03) : 2734 - 2737
  • [44] Atrial fibrillation-induced cardiac troponin I release
    Parwani, Abdul S.
    Boldt, Leif-Hendrik
    INTERNATIONAL JOURNAL OF CARDIOLOGY, 2014, 172 (01) : 220 - 220
  • [45] Malondialdehyde and cardiac troponin I in Arabian horses subjected to exercise and vitamin E supplementation
    Yonezawa, Leticia Andreza
    Machado, Luciana Pereira
    da Silveira, Veridiana Fernandes
    Watanabe, Marcos Jun
    Saito, Mere Erika
    Kitamura, Sandra Satiko
    Kohayagawa, Aguemi
    CIENCIA RURAL, 2010, 40 (06): : 1321 - 1326
  • [46] Comparison of cardiac Troponin T and cardiac Troponin I concentrations in peripheral blood during orciprenaline induced tachycardia in rats
    Bertsch, T
    Bleuel, H
    Aufenanger, J
    Rebel, W
    EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 1997, 49 (06) : 467 - 468
  • [47] Neuregulin-1 Alleviated Doxorubicin-Induced Downregulation of Cardiac Troponin I and Cardiac Troponin T in the Heart
    Bian, Yun
    Sun, Maoyun
    Silver, Marcy
    Ho, Kalon K.
    Marchionni, Mark A.
    Caggiano, Anthony
    Kang, Peter M.
    Morgan, James P.
    Yan, Xinhua
    CIRCULATION RESEARCH, 2008, 103 (05) : E68 - E69
  • [48] Ras induced Gαi signaling in cardiac dysfunction and arrhythmias
    Ruan, Hongmei
    Mitchell, Scherise
    Goldhaber, Joshua I.
    Wang, Yibin
    CIRCULATION, 2006, 114 (18) : 268 - 268
  • [49] Rapid screening for cardiac arrhythmias in competition draft horses
    Gallant, L. R.
    Jacob, S., I
    Tadros, E. M.
    Woodrow, J. S.
    Hines, M. T.
    Ewart, S. L.
    Schott, H. C., II
    COMPARATIVE EXERCISE PHYSIOLOGY, 2019, 15 (04) : 291 - 298
  • [50] Computational binding study of cardiac troponin I antibody towards cardiac versus skeletal troponin I
    Sabek, Jad
    Martinez-Perez, Paula
    Garcia-Ruperez, Jaime
    COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2019, 80 : 147 - 151