Carbohydrate-based templates for synthetic vaccines and drug delivery

被引：30
|
作者：
McGeary, RP
Jablonkai, I
Toth, I
机构：
[1] Univ Queensland, Sch Pharm, Brisbane, Qld 4072, Australia
[2] Alchemia Pty Ltd, Hi Tech Court 3, Brisbane, Qld 4113, Australia
[3] Univ London, Sch Pharm, Dept Pharmaceut & Biol Sci, London W1CN 1AX, England
[4] Hungarian Acad Sci, Chem Res Ctr, Inst Chem, H-1025 Budapest, Hungary
来源：
TETRAHEDRON | 2001年 / 57卷 / 41期
基金：
英国惠康基金;
关键词：
synthetic vaccines; carbohydrates; solid-phase synthesis; adjuvants/carriers;
D O I：
10.1016/S0040-4020(01)00852-3
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Methyl tetra-O-allyl, and tetra-O-[2-(tetrahydro-2H-pyranyl)oxy.-3-oxapentyl glucosides, and tetra-O-(cyanoethyl)galactosyl azide were converted into derivatives containing linkers with terminal carboxylic acid functionalities at the anomeric position and bearing four arms with phthaloyl- or BOC-protected terminal amino groups. These molecules were suitable for use in solid-phase peptide synthesis and for the preparation of dendrimers, containing multiple copies of peptides. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：8733 / 8742
页数：10
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