HPLC-EAT (Environmental Assessment Tool): A tool for profiling safety, health and environmental impacts of liquid chromatography methods

被引：158
|
作者：
Gaber, Yasser [1 ,2 ]
Tornvall, Ulrika [1 ]
Kumar, M. A. [1 ,3 ]
Amin, Magdy Ali [4 ]
Hatti-Kaul, Rajni [1 ]
机构：
[1] Lund Univ, Dept Biotechnol, Ctr Chem & Chem Engn, SE-22100 Lund, Sweden
[2] Beni Suef Univ, Dept Microbiol, Fac Pharm, Bani Suwayf 62111, Egypt
[3] Infosys Technol Ltd, Mysore, Karnataka, India
[4] Cairo Univ, Microbial Biotechnol Ctr, Fac Pharm, Cairo, Egypt
来源：
GREEN CHEMISTRY | 2011年 / 13卷 / 08期
关键词：
EVAPORATIVE LIGHT-SCATTERING; LIPID CLASSES; SEPARATION; SURFACTANTS; PHASE;
D O I：
10.1039/c0gc00667j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A simple and efficient approach for profiling the greenness of high performance liquid chromatography (HPLC) methods is presented. This environmental assessment tool (EAT) takes into consideration the environmental, health and safety issues for all solvents involved in the chromatographic method, and calculates a total score that can be used for comparison of the greenness of different methods. A software, HPLC-EAT, has been designed to facilitate the calculation and can be downloaded free of charge at http://www.biotek.lu.se/hplc-eat/. HPLC-EAT was successfully applied for a set of different HPLC methods from the literature, including both analytical and preparative chromatography. The performance of the tool was validated and it was further combined with another free software Eco-solvent tool to perform life cycle assessments of waste disposal options of distillation or incineration. HPLC-EAT can be routinely used in method development to calculate the greenness beside the conventional standards of accuracy, robustness and reproducibility.
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页码：2021 / 2025
页数：5
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