Oxidative stress-related gene interactions with preterm delivery in Korean women

OBJECTIVE: We hypothesized that the cytochrome P4501A1 (CYP1A1), glutathione S-transferases mu 1 (GSTM1), and theta 1 (GSTT1) polymorphisms are associated with the risk for preterm delivery. This study was undertaken to identify gene-gene interactions and haplotypes that increase the risk of preterm delivery. STUDY DESIGN: This case-control study was performed in Korea on 145 women with preterm birth and 120 normal controls. Logistic regression and multifactor dimensionality reduction analysis were used to explore single genes and gene-gene interactions, which have an impact on the risk of preterm delivery, respectively. RESULTS: The GSTM1 null genotype and the interaction between the CYP1A1-1462V and GSTM1 null type conferred a risk of preterm birth. The association between preterm delivery and the CYP1A1-T6235C/1462V haplotype plus GSTM1 null type was verified. CONCLUSION: The interaction between the CYP1A1-1462V and GSTM1 null genotype were found to increase the risk for preterm birth in Korean women. This finding provides evidence of a gene-gene interaction, which has an impact on preterm delivery.