pH-Responsive near-infrared fluorescent cyanine dyes for molecular imaging based on pH sensing

被引：38

作者：

Miki, Koji ^{[1
]}

Kojima, Kentaro ^{[1
]}

Oride, Kazuaki ^{[1
]}

Harada, Hiroshi ^{[2
]}

Morinibu, Akiyo ^{[2
]}

Ohe, Kouichi ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Engn, Dept Energy & Hydrocarbon Chem, Nishikyo Ku, Kyoto 6158510, Japan

[2] Kyoto Univ, Ctr Radiat Biol, Canc Cell Biol Lab, Sakyo Ku, Yoshida Konoe Cho, Kyoto 6068501, Japan

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 55期

基金：

日本科学技术振兴机构;

关键词：

TUMORS IN-VIVO; BIOLOGICAL APPLICATIONS; OPTICAL-PROPERTIES; INDOCYANINE GREEN; PROBES; CELLS; NANOPARTICLES; CARBOCYANINE; LIFETIME; REGIONS;

D O I：

10.1039/c7cc03035e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Indocyanine green (ICG) derivatives having nucleophilic substituents were synthesized as pH-responsive near-infrared dyes. pH-responsive dyes 1-C with closed-ring structures smoothly internalized and converted to emissive open-ring structures 1-O in response to relatively low pHs in acidic intracellular compartments of HeLa cells.

引用

页码：7792 / 7795

页数：4

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