Construction and Aromatization of Hantzsch 1,4-Dihydropyridines under Microwave Irradiation: A Green Approach

被引：13
|
作者：
Heravi, Majid M. [1 ]
Zadsirjan, Vahideh [1 ]
机构：
[1] Alzahra Univ, Fac Chem & Phys, Dept Chem, Tehran, Iran
来源：
CHEMISTRYSELECT | 2022年 / 7卷 / 03期
基金：
美国国家科学基金会;
关键词：
1; 4-Dihydropyridines; Green Chemistry; Hantzsch reaction; Microwave Irradiation; ONE-POT SYNTHESIS; ASSISTED ORGANIC-SYNTHESIS; DILUTE-ACID HYDROLYSIS; SOLVENT-FREE SYNTHESIS; POLYHYDROQUINOLINE DERIVATIVES; HETEROCYCLIC-COMPOUNDS; PRIVILEGED SYNTHONS; BIGINELLI REACTION; IONIC LIQUID; MULTICOMPONENT REACTIONS;
D O I：
10.1002/slct.202104032
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Hantzsch reaction, leading to the synthesis of 1,4-dihydropyridines (1,4-DHPs) with momentous biological activities and pharmacological properties is a well-known MCR. In recent years, microwave irradiation (MWI) has been successfully used as the unconventional and green source of energy to promote organic transformations including Hantzsch 1,4-dihydropyridines. Literature survey disclosed that construction of 1,4-DHPs as well as their aromatization can be successfully performed under MWI in solution as well as in dry media. In this review, we try to underscore recent advances in the synthesis and aromatization of Hantzsch 1,4-DHPs under MWI as green approach.
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页数：34
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