Investigation of newly synthesized endothelin peptides by high-performance liquid chromatography coupled to electrospray mass spectrometry

被引：0
|
作者：
Rovatti, L
Curcuruto, O
Hamdan, M
Cassano, E
Galoppini, C
Rovero, P
机构：
[1] GLAXO WELLCOME MED RES CTR,I-37134 VERONA,ITALY
[2] CNR,IST MUTAGENESI & DIFFERENZIAMENTO,I-56124 PISA,ITALY
来源：
RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 1996年 / 10卷 / 12期
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A number of newly synthesized endothelin peptides have been examined by high performance liquid chromatography/electrospray mass spectrometry (HPLC/ES-MS). The presented data allowed reliable identification of both the target peptides and a number of associated side products including the target peptide in methylated form and peptide sequences with relative molecular masses lower than those desired. Characteristic fragments in the ES mass spectra permitted differentiation between the methylation sites involving the carboxylic functions of the C-terminus and the side-chain of the aspartic acid.
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页码：1504 / 1508
页数：5
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