Rhodium-catalyzed coupling of α-lactams with indole derivatives

被引：3

作者：

Box, Hannah K. ^{[1
]}

Kumarasinghe, K. G. Upul ^{[1
]}

Nareddy, Radhika R. ^{[1
]}

Akurathi, Gopalakrishna ^{[1
]}

Chakraborty, Amarraj ^{[1
]}

Raji, Babatunde ^{[1
]}

Rowland, Gerald B. ^{[1
,2
]}

机构：

[1] Mississippi State Univ, Dept Chem, Mississippi State, MS 39762 USA

[2] Univ Mississippi, Dept Chem & Biochem, University, MS 38677 USA

来源：

TETRAHEDRON | 2014年 / 70卷 / 51期

关键词：

alpha-Lactams; C-N bond formation; Indo; CYCLOADDITION REACTIONS; ALKYLATION; COMPLEXES; AMINATION; ARYLATION;

D O I：

10.1016/j.tet.2014.10.049

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report herein a method that allows for the formation of a C-N bond between the C-3 carbon of alactams and the nitrogen atom of indoles. A general procedure for the coupling of indoles and alpha-lactams in only 25 mm with high yield is reported. The scope of the reaction was extended by the development of a method for the in situ generation of less stable phenyl-substituted a-lactams. The developed method provides an atom-economical method for the formation of substituted a-amino amides that are found in a variety of biologically-active compounds. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：9709 / 9717

页数：9

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