Neutral merocyanine dyes: for in vivo NIR fluorescence imaging of amyloid-β plaques

被引：55

作者：

Yan, Jin-wu ^{[1
]}

Zhu, Jia-ying ^{[1
]}

Zhou, Kai-xiang ^{[2
]}

Wang, Jin-sheng ^{[1
]}

Tan, Hui-ya ^{[1
]}

Xu, Zhong-yong ^{[1
]}

Chen, Shuo-bin ^{[3
]}

Lu, Yu-ting ^{[3
]}

Cui, Meng-chao ^{[2
]}

Zhang, Lei ^{[1
]}

机构：

[1] South China Univ Technol, Sch Biol & Biol Engn, Guangzhou, Guangdong, Peoples R China

[2] Beijing Normal Univ, Coll Chem, Key Lab Radiopharmaceut, Minist Educ, Beijing 100875, Peoples R China

[3] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 71期

基金：

中国国家自然科学基金;

关键词：

ALZHEIMERS-DISEASE; PROBES; MITOCHONDRIA; IR-780;

D O I：

10.1039/c7cc05056a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two neutral merocyanine-based near-infrared fluorescent probes were for the first time developed through rational engineering of the classical cationic cyanine scaffold IR-780 for in vivo imaging of amyloid-beta plaques. In vivo NIRF imaging revealed that the probe could penetrate the blood-brain barrier and efficiently differentiate the living transgenic and wild-type mice.

引用

页码：9910 / 9913

页数：4

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