Photocleavable molecule for laser desorption ionization mass spectrometry

被引：13
|
作者：
Maki, Toshihide
Ishida, Koji
机构：
[1] Nagasaki Univ, Joint Res Ctr, Nagasaki 8528521, Japan
[2] Nagasaki Univ, Grad Sch Biomed Sci, Nagasaki 8528521, Japan
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 17期
关键词：
D O I：
10.1021/jo070621b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new photocleavable molecule for laser desorption ionization mass spectrometry (LDI-MS) was designed and synthesized. The molecule exhibited high sensitivity for negative mode MS detection with good chemical stability. The molecule was successfully applied to molecular tag for (LDI-MS). Kinetic measurement of the amidation reaction and monitoring of aminolysis of acetylated sugars were demonstrated with the molecular tag.
引用
收藏
页码：6427 / 6433
页数：7
相关论文
共 50 条
  • [1] Matrix-assisted laser desorption/ionization mass spectrometry of DNA using photocleavable biotin
    Hahner, S
    Olejnik, J
    Lüdemann, HC
    Krzymañska-Olejnik, E
    Hillenkamp, F
    Rothschild, KJ
    BIOMOLECULAR ENGINEERING, 1999, 16 (1-4): : 127 - 133
  • [2] Concise Synthesis of Photocleavable Molecular Tag for Laser Desorption Ionization Mass Spectrometry via Fries Reaction
    Gathirwa, Jeremiah W.
    Maki, Toshihide
    SYNTHETIC COMMUNICATIONS, 2013, 43 (07) : 1016 - 1022
  • [3] Nanoparticle assisted laser desorption/ionization mass spectrometry for small molecule analytes
    Abdelhamid, Hani Nasser
    MICROCHIMICA ACTA, 2018, 185 (03)
  • [4] Nanoparticle assisted laser desorption/ionization mass spectrometry for small molecule analytes
    Hani Nasser Abdelhamid
    Microchimica Acta, 2018, 185
  • [5] Electrospray laser desorption ionization mass spectrometry
    Huang, Min-Zong
    Jhang, Siou-Sian
    Chan, Ya-Ting
    Cheng, Sy-Chi
    Cheng, Chun-Nian
    Shiea, Jentaie
    New Developments in Mass Spectrometry, 2015, 2015-January (02): : 372 - 388
  • [6] Preparation and evaluation of in situ photocleavable mass tags with facile mass variation for matrix-free laser desorption ionization mass spectrometry
    Na, Jin-Gyu
    Ji, Seokhwan
    Kang, Hyunook
    Yeo, Woon-Seok
    ANALYTICAL METHODS, 2024, 16 (13) : 1856 - 1861
  • [7] LASER-DESORPTION MASS-SPECTROMETRY MASS-SPECTROMETRY AND THE MECHANISM OF DESORPTION IONIZATION
    ZAKETT, D
    SCHOEN, AE
    COOKS, RG
    HEMBERGER, PH
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (05) : 1295 - 1297
  • [8] Silver nanostructures in laser desorption/ionization mass spectrometry and mass spectrometry imaging
    Sekula, Justyna
    Niziol, Joanna
    Rode, Wojciech
    Ruman, Tomasz
    ANALYST, 2015, 140 (18) : 6195 - 6209
  • [9] LASER DESORPTION CHEMICAL IONIZATION MASS-SPECTROMETRY MASS-SPECTROMETRY
    PERCHALSKI, RJ
    YOST, RA
    WILDER, BJ
    ANALYTICAL CHEMISTRY, 1983, 55 (12) : 2002 - 2005
  • [10] Role of electrons in laser desorption/ionization mass spectrometry
    Frankevich, VE
    Zhang, J
    Friess, SD
    Dashtiev, M
    Zenobi, R
    ANALYTICAL CHEMISTRY, 2003, 75 (22) : 6063 - 6067
12345