S100A6 promotes proliferation of intrahepatic cholangiocarcinoma cells via the activation of the p38/MAPK pathway

被引：13
|
作者：
Zheng, Susu [1 ,2 ]
Shen, Hujia [1 ,2 ]
Jia, Qingan [1 ,2 ]
Jing, Chuyu [1 ,2 ]
Lin, Jiajia [1 ,2 ]
Zhang, Meixia [1 ,2 ]
Zhang, Xiaolei [3 ]
Zhang, Boheng [1 ,2 ]
Liu, Yinkun [1 ,2 ]
机构：
[1] Fudan Univ, Liver Canc Inst, Dept Hepat Oncol, Shanghai 20032, Peoples R China
[2] Fudan Univ, Zhongshan Hosp, Shanghai 20032, Peoples R China
[3] Fudan Univ, Zhongshan Hosp, Dept Pathol, Shanghai 20032, Peoples R China
来源：
FUTURE ONCOLOGY | 2017年 / 13卷 / 23期
基金：
中国国家自然科学基金;
关键词：
intrahepatic cholangiocarcinoma; prognosis; proliferation; S100A6; HUMAN HEPATOCELLULAR-CARCINOMA; GASTRIC-CANCER; THERAPEUTIC TARGET; MAPK PATHWAYS; EXPRESSION; PROTEIN; KINASE; CALCYCLIN; MIGRATION; GROWTH;
D O I：
10.2217/fon-2017-0199
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: We explored the expression of S100A6 and its role in intrahepatic cholangiocarcinoma (ICC). Methods: The expression of S100A6 in ICC samples was detected by immunohistochemistry. In vitro experiments, we silenced and overexpressed S100A6 to investigate its role in cell functions. Results: The expression of S100A6 was markedly increased in ICC tissues and cell lines. S100A6 overexpression was an independent risk factor for patients' survival. Silencing S100A6 resulted in a suppression of proliferation and p38/MAPK activity, while overexpressing S100A6 caused a promotion of proliferation and p38/MAPK. Discussion: S100A6 participated in the proliferation of ICC cells and correlated with a more aggressive behavior of ICC. Conclusion: S100A6 may serve as a novel prognostic marker and a potential therapeutic target for ICC patients.
引用
收藏
页码：2053 / 2063
页数：11
相关论文
共 50 条
  • [31] Interlukin-17A Promotes Aortic Endothelial Activation Via Transcriptionally and Post Transcriptionally Activating p38 MAPK Pathway
    Mai, Jietang
    Nanayakkara, Gayani
    Lopez-Pastrana, Jahaira
    Li, Xinyuan
    Li, Ya-Feng
    Wang, Xin
    Virtue, Anthony
    Shao, Ying
    Shan, Huimin
    Liu, Fang
    Autieri, Michael
    Iwakura, Yoichiro
    Jiang, Xiaohua
    Wang, Hong
    Yang, Xiao-Feng
    FASEB JOURNAL, 2016, 30
  • [32] Hesperetin Induces Apoptosis in Human Glioblastoma Cells via p38 MAPK Activation
    Li, Qiang
    Miao, Ziwei
    Wang, Rui
    Yang, Jun
    Zhang, Dianbao
    NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2020, 72 (03): : 538 - 545
  • [33] Triptolide promotes autophagy to inhibit mesangial cell proliferation in IgA nephropathy via the CARD9/p38 MAPK pathway
    Zhao, Lu
    Lan, Zhixin
    Peng, Liang
    Wan, Lili
    Liu, Di
    Tan, Xia
    Tang, Chengyuan
    Chen, Guochun
    Liu, Hong
    CELL PROLIFERATION, 2022, 55 (09)
  • [34] Selective Activation of the p38 MAPK Pathway by Synthetic Monophosphoryl Lipid A
    Cekic, Caglar
    Casella, Carolyn R.
    Eaves, Chelsea A.
    Matsuzawa, Atsushi
    Ichijo, Hidenori
    Mitchell, Thomas C.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (46) : 31982 - 31991
  • [35] Baicalin Promotes Apoptosis of Human Medullary Breast Cancer via the ERK/p38 MAPK Pathway
    Li, Xianyong
    Tang, Qianqian
    Li, Wenwei
    Zhan, Dongzai
    Fang, Xiangyang
    Huang, Shengchao
    Shui, Xiaorong
    Li, Jianwen
    PHARMACOGNOSY MAGAZINE, 2024, 20 (02) : 563 - 571
  • [36] IL-1β promotes neurite outgrowth by deactivating RhoA via p38 MAPK pathway
    Temporin, Ko
    Tanaka, Hiroyuki
    Kuroda, Yusuke
    Okada, Kiyoshi
    Yachi, Koji
    Moritomo, Hisao
    Murase, Tsuyoshi
    Yoshikawa, Hideki
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 365 (02) : 375 - 380
  • [37] Transient hypoxia-induced proliferation is mediated via p38 MAPK in endothelial cells
    Arshad, M
    Holl, M
    Aslam, M
    Härtel, F
    Noll, T
    JOURNAL OF VASCULAR RESEARCH, 2005, 42 : 89 - 89
  • [38] S100A9 promotes the proliferation and invasion of HepG2 hepatocellular carcinoma cells via the activation of the MAPK signaling pathway
    Wu, Rui
    Duan, Liang
    Ye, Liwei
    Wang, Haiyang
    Yang, Xia
    Zhang, Yunyuan
    Chen, Xian
    Zhang, Yan
    Weng, Yaguang
    Luo, Jingyong
    Tang, Min
    Shi, Qiong
    He, Tongchuan
    Zhou, Lan
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2013, 42 (03) : 1001 - 1010
  • [39] G6PD knockdown-mediated impairment of inflammasome activation via dysregulation of p38/MAPK pathway
    Yen, Wei-Chen
    Wu, Chih-Ching
    Wu, Yi-Hsuan
    Chiu, Daniel Tsun-Yee
    FREE RADICAL BIOLOGY AND MEDICINE, 2018, 128 : S113 - S113
  • [40] S100A6 promotes proliferation and migration of HepG2 cells via increased ubiquitin-dependent degradation of p53
    Song, Dongqiang
    Xu, Beili
    Shi, Dongmin
    Li, Shuyu
    Cai, Yu
    OPEN MEDICINE, 2020, 15 (01): : 317 - 326
12345