Redox-neutral rhodium(iii)-catalyzed chemo- and regiospecific [4+1] annulation between benzamides and alkenes for the synthesis of functionalized isoindolinones

被引：0

作者：

Qiao, Jin ^{[1
,2
]}

Mao, Hui ^{[1
]}

Lu, Shiyao ^{[2
]}

Zhang, Xiaoning ^{[2
]}

Ni, Hangcheng ^{[2
]}

Lu, Yangbin ^{[2
]}

机构：

[1] Jinhua Polytech, Coll Pharm, Jinhua 321007, Zhejiang, Peoples R China

[2] Chengdu Univ, Sch Pharm, Sichuan Ind Inst Antibiot, Jinhua Branch, Jinhua 321007, Zhejiang, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 19卷 / 45期

关键词：

C-H FUNCTIONALIZATION; BOND FUNCTIONALIZATIONS; DIVERGENT SYNTHESIS; PROPARGYL ALCOHOLS; SELECTIVE ACCESS; OLEFINATION; ACTIVATION; ALKENYLATIONS; CYCLIZATION; MALEIMIDES;

D O I：

10.1039/d1ob01792f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, using electron-deficient alkenes embedded with an oxidizing function/leaving group as a rare and nontraditional C-1 synthon, we have achieved the redox-neutral Rh(iii)-catalyzed chemo- and regioselective [4 + 1] annulation of benzamides for the synthesis of functionalized isoindolinones. This method features broad substrate scope, good to excellent yields, excellent chemo- and regioselectivity, good tolerance of functional groups and mild external-oxidant-free conditions.

引用

页码：9946 / 9952

页数：7

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