Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity

被引：8

作者：

Popovici, Corina ^{[1
,2
]}

Pavel, Cristina-Maria ^{[3
]}

Sunel, Valeriu ^{[1
]}

Cheptea, Corina ^{[4
]}

Dimitriu, Dan Gheorghe ^{[3
]}

Dorohoi, Dana Ortansa ^{[3
]}

David, Diana ^{[5
]}

Closca, Valentina ^{[3
,6
]}

Popa, Marcel ^{[2
]}

机构：

[1] Alexandru Ioan Cuza Univ, Fac Chem, 11 Carol Blvd, Iasi 700506, Romania

[2] Gheorghe Sachi Tech Univ, Fac Chem Engn & Environm Protect, Dept Nat & Synthet Polymers, 73 Prof Dimitrie Mangeron Blvd, Iasi 700050, Romania

[3] Alexandru Ioan Cuza Univ, Fac Phys, 11 Carol Blvd, Iasi 700506, Romania

[4] Grigore T Popa Univ Med & Pharm, Dept Biomed Sci, Fac Med Bioengn, 9-13 M Kogalniceanu Str, Iasi 700454, Romania

[5] Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England

[6] Eudoxiu Hurmuzachi Natl Coll, Dept Sci, 5 Calea Bucovinei Str, Radauti 725400, Romania

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 22期

关键词：

2-mercapto-benzimidazole; sulfonic derivatives; heterocyclic thiosemicarbazides; tuberculostatic activity; ANTIMICROBIAL ACTIVITY; COMPLEXES; 1,2,4-TRIAZOLO;

D O I：

10.3390/ijms222212139

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Original results are presented in the field of research that addresses the extension of the reaction of residue of acyl-thiosemicarbazide fixation on the structure of 5-nitrobenzimidazole by a sulphonic group. The aim of the study is the increase of new thiosemicarbazide derivatives' applicative potential in the field of biochemistry, with a wide range of medical applications. The newly obtained compounds were characterized by using elemental analysis and spectral analysis (FT-IR and H-1 NMR). A study regarding the optimization of the chemical reactions was made. The performed in vitro biological tests confirmed the tuberculostatic activity of three newly obtained compounds against Mycobacterium tuberculosis.

引用

页数：14

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