Cytoplasmic gene expression: lessons from poxviruses

被引：9

作者：

Grimm, Clemens ^{[1
,2
]}

Bartuli, Julia ^{[1
,2
]}

Fischer, Utz ^{[1
,2
,3
]}

机构：

[1] Univ Wurzburg, Theodor Boveri Inst, Dept Biochem, D-97074 Wurzburg, Germany

[2] Univ Wurzburg, Theodor Boveri Inst, Canc Therapy Res Ctr CTRC, D-97074 Wurzburg, Germany

[3] Helmholtz Ctr Infect Res HZI, Helmholtz Inst RNA Based Infect Res HIRI, D-97080 Wurzburg, Germany

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2022年 / 47卷 / 10期

关键词：

VACCINIA VIRUS INTERMEDIATE; TRANSCRIPTION START SITE; RNA CAPPING ENZYME; MESSENGER-RNA; STRUCTURAL INSIGHTS; POLYMERASE; MECHANISM; TERMINATION; INITIATION; EVOLUTION;

D O I：

10.1016/j.tibs.2022.04.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In eukaryotic cells, the process of gene expression is confined to the nucleus and enabled by multisubunit RNA polymerases (RNAPs). Many viruses make use of the host cellular gene expression apparatus during infection, and hence transfer their genome at least transiently to the host nucleus. However, poxviruses have evolved a different strategy to propagate. Their double-stranded DNA genome is transcribed in the host cytoplasm by a virus-encoded RNAP (vRNAP), which is evolutionarily related to eukaryotic RNA polymerase II. In this Review, we high-light recent high-resolution structures of the poxviral transcription apparatus in different phases of action. These structures, along with biochemical data, now allow the definition of a comprehensive model of poxviral gene expression and its regulation.

引用

页码：892 / 902

页数：11

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