Prospective trial of metronomic chlorambucil chemotherapy in dogs with naturally occurring cancer

被引:49
|
作者
Leach, T. N. [1 ]
Childress, M. O. [1 ]
Greene, S. N. [2 ]
Mohamed, A. S. [3 ]
Moore, G. E. [3 ]
Schrempp, D. R. [1 ]
Lahrman, S. R. [1 ]
Knapp, D. W. [1 ,4 ]
机构
[1] Purdue Univ, Dept Vet Clin Sci, Sch Vet Med, W Lafayette, IN 47907 USA
[2] VCA Aurora Anim Hosp, Aurora, CO USA
[3] Purdue Univ, Dept Comparat Pathobiol, Sch Vet Med, W Lafayette, IN 47907 USA
[4] Purdue Univ, Ctr Canc Res, W Lafayette, IN 47907 USA
关键词
antiangiogenesis; chemotherapy; chlorambucil; metronomic; oncology; CELL-LUNG-CANCER; CHRONIC LYMPHOCYTIC-LEUKEMIA; DOSE ORAL CYCLOPHOSPHAMIDE; BREAST-CANCER; PHASE-II; THROMBOSPONDIN-1; PHARMACOKINETICS; THERAPY; METABOLISM; ETOPOSIDE;
D O I
10.1111/j.1476-5829.2011.00280.x
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
The purpose of this study was to assess the toxicoses and antitumor activity of metronomic chlorambucil at a dosage of 4 mg m-2 daily in dogs with naturally occurring cancer. Thirty-six dogs were enrolled in the study. The protocol was well tolerated with no grade 3 or 4 toxicoses noted. Complete remission was achieved, and lasted over 35 weeks in three dogs (mast cell tumour, soft tissue sarcoma and thyroid carcinoma). Partial remission was noted in 1 dog with histiocytic sarcoma (39 weeks duration) for an overall remission rate of 11% (4 of 36). Stable disease was noted in 17 dogs (47%) with various other cancers. The median progression-free interval was 61 days, and the median survival time was 153 days. Chlorambucil given in a metronomic protocol showed antitumor activity in dogs with a variety of naturally occurring cancers.
引用
收藏
页码:102 / 112
页数:11
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