Prospective trial of metronomic chlorambucil chemotherapy in dogs with naturally occurring cancer
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作者:
Leach, T. N.
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Purdue Univ, Dept Vet Clin Sci, Sch Vet Med, W Lafayette, IN 47907 USAPurdue Univ, Dept Vet Clin Sci, Sch Vet Med, W Lafayette, IN 47907 USA
Leach, T. N.
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Childress, M. O.
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Purdue Univ, Dept Vet Clin Sci, Sch Vet Med, W Lafayette, IN 47907 USAPurdue Univ, Dept Vet Clin Sci, Sch Vet Med, W Lafayette, IN 47907 USA
Childress, M. O.
[1
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Greene, S. N.
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VCA Aurora Anim Hosp, Aurora, CO USAPurdue Univ, Dept Vet Clin Sci, Sch Vet Med, W Lafayette, IN 47907 USA
Greene, S. N.
[2
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Mohamed, A. S.
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Purdue Univ, Dept Comparat Pathobiol, Sch Vet Med, W Lafayette, IN 47907 USAPurdue Univ, Dept Vet Clin Sci, Sch Vet Med, W Lafayette, IN 47907 USA
Mohamed, A. S.
[3
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Moore, G. E.
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Purdue Univ, Dept Comparat Pathobiol, Sch Vet Med, W Lafayette, IN 47907 USAPurdue Univ, Dept Vet Clin Sci, Sch Vet Med, W Lafayette, IN 47907 USA
Moore, G. E.
[3
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Schrempp, D. R.
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Purdue Univ, Dept Vet Clin Sci, Sch Vet Med, W Lafayette, IN 47907 USAPurdue Univ, Dept Vet Clin Sci, Sch Vet Med, W Lafayette, IN 47907 USA
Schrempp, D. R.
[1
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Lahrman, S. R.
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Purdue Univ, Dept Vet Clin Sci, Sch Vet Med, W Lafayette, IN 47907 USAPurdue Univ, Dept Vet Clin Sci, Sch Vet Med, W Lafayette, IN 47907 USA
Lahrman, S. R.
[1
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Knapp, D. W.
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Purdue Univ, Dept Vet Clin Sci, Sch Vet Med, W Lafayette, IN 47907 USA
Purdue Univ, Ctr Canc Res, W Lafayette, IN 47907 USAPurdue Univ, Dept Vet Clin Sci, Sch Vet Med, W Lafayette, IN 47907 USA
Knapp, D. W.
[1
,4
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机构:
[1] Purdue Univ, Dept Vet Clin Sci, Sch Vet Med, W Lafayette, IN 47907 USA
[2] VCA Aurora Anim Hosp, Aurora, CO USA
[3] Purdue Univ, Dept Comparat Pathobiol, Sch Vet Med, W Lafayette, IN 47907 USA
[4] Purdue Univ, Ctr Canc Res, W Lafayette, IN 47907 USA
The purpose of this study was to assess the toxicoses and antitumor activity of metronomic chlorambucil at a dosage of 4 mg m-2 daily in dogs with naturally occurring cancer. Thirty-six dogs were enrolled in the study. The protocol was well tolerated with no grade 3 or 4 toxicoses noted. Complete remission was achieved, and lasted over 35 weeks in three dogs (mast cell tumour, soft tissue sarcoma and thyroid carcinoma). Partial remission was noted in 1 dog with histiocytic sarcoma (39 weeks duration) for an overall remission rate of 11% (4 of 36). Stable disease was noted in 17 dogs (47%) with various other cancers. The median progression-free interval was 61 days, and the median survival time was 153 days. Chlorambucil given in a metronomic protocol showed antitumor activity in dogs with a variety of naturally occurring cancers.
机构:
Sapienza Univ, St Andrea Hosp, Med Oncol Unit, Via Grottarossa 1035-1039, I-00189 Rome, ItalySapienza Univ, St Andrea Hosp, Med Oncol Unit, Via Grottarossa 1035-1039, I-00189 Rome, Italy
Romiti, Adriana
Falcone, Rosa
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Sapienza Univ, St Andrea Hosp, Med Oncol Unit, Via Grottarossa 1035-1039, I-00189 Rome, ItalySapienza Univ, St Andrea Hosp, Med Oncol Unit, Via Grottarossa 1035-1039, I-00189 Rome, Italy
Falcone, Rosa
Roberto, Michela
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Sapienza Univ, St Andrea Hosp, Med Oncol Unit, Via Grottarossa 1035-1039, I-00189 Rome, ItalySapienza Univ, St Andrea Hosp, Med Oncol Unit, Via Grottarossa 1035-1039, I-00189 Rome, Italy
Roberto, Michela
Marchetti, Paolo
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Sapienza Univ, St Andrea Hosp, Med Oncol Unit, Via Grottarossa 1035-1039, I-00189 Rome, ItalySapienza Univ, St Andrea Hosp, Med Oncol Unit, Via Grottarossa 1035-1039, I-00189 Rome, Italy
机构:
Catholic Univ Korea, Div Med Oncol, Dept Internal Med, Yeouido St Marys Hosp,Coll Med, 10,63 Ro, Seoul 07345, South KoreaCatholic Univ Korea, Div Med Oncol, Dept Internal Med, Yeouido St Marys Hosp,Coll Med, 10,63 Ro, Seoul 07345, South Korea
机构:
Colorado State Univ, Vet Teaching Hosp, 300 W Drake Rd, Ft Collins, CO 80523 USAColorado State Univ, Vet Teaching Hosp, 300 W Drake Rd, Ft Collins, CO 80523 USA
Baker-Meuten, Alice
Wendland, Theresa
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Colorado State Univ, Vet Teaching Hosp, 300 W Drake Rd, Ft Collins, CO 80523 USAColorado State Univ, Vet Teaching Hosp, 300 W Drake Rd, Ft Collins, CO 80523 USA
Wendland, Theresa
Shamir, Shelly K.
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Univ Minnesota, Vet Med Ctr, 1365 Gortner Ave, St Paul, MN 55108 USAColorado State Univ, Vet Teaching Hosp, 300 W Drake Rd, Ft Collins, CO 80523 USA
Shamir, Shelly K.
Hess, Ann M.
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Colorado State Univ, Dept Stat, 300 W Drake Rd, Ft Collins, CO 80523 USAColorado State Univ, Vet Teaching Hosp, 300 W Drake Rd, Ft Collins, CO 80523 USA
Hess, Ann M.
Duerr, Felix Michael
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Colorado State Univ, Vet Teaching Hosp, 300 W Drake Rd, Ft Collins, CO 80523 USAColorado State Univ, Vet Teaching Hosp, 300 W Drake Rd, Ft Collins, CO 80523 USA