A Phytochemical Approach to Experimental Metabolic Syndrome-Associated Renal Damage and Oxidative Stress

被引:1
|
作者
Marotta, Francesco [1 ]
Kumari, Archana [2 ]
Catanzaro, Roberto [3 ]
Solimene, Umberto [4 ]
Jain, Shalini [5 ]
Minelli, Emilio [4 ]
Harada, Masatoshi [6 ]
机构
[1] ReGenera Res Grp Aging Intervent, I-20154 Milan, Italy
[2] Univ Quebec, Inst Natl Rech Sci, Ctr Eau Terre & Environm, Quebec City, PQ, Canada
[3] Univ Catania, Dept Internal Med, Gastroenterol Unit, Catania, Italy
[4] Univ Milan, WHO Ctr Biotechnol & Tradit Med, Milan, Italy
[5] NIDDK, NIH, Bethesda, MD USA
[6] MCH Hosp, Saitama, Japan
关键词
CARDIOVASCULAR-DISEASE; KIDNEY-DISEASE; FRUCTOSE; HYPERTENSION; NOTOGINSENG; MORTALITY; EXTRACTS;
D O I
10.1089/rej.2011.1266
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
The aim of this study was to evaluate the effect of DTS-phytocompound on oxidant-antioxidant balance and protein damage in the kidneys of rats administered high doses of fructose. Adult male Wistar rats were divided into four groups. Group A received a control diet, whereas groups B and C were fed a high-fructose diet (60 g/100 g), the latter with additional DTS (50 mg/kg per day) for 60 days. Lipo-and nitro-peroxidation together with alpha-smooth muscle actin (alpha-SMA) expression in the glomerular and interstitial tissue of the kidneys were measured after 60 days. Fructose-fed rats showed significantly higher lipoperoxidation, 2,4-dinitrophenol and 3-nitrotyrosine protein adducts, and upregulation of alpha-SMA in the kidney. DTS significantly decreased such redox unbalance in renal tissue, while partially downregulating alpha-SMA (p < 0.01). These data suggest the potential clinical benefit of DTS in protecting the kidneys from metabolic syndrome-associated changes; gender-related analysis is under way.
引用
收藏
页码:153 / 156
页数:4
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