Epiglottic Squamous Cell Carcinoma Showing Unexpected 18F-FDOPA Uptake on PET/CT Investigation

被引：4
|
作者：
Dietemann, Sebastien [1 ]
Debry, Christian [2 ]
Onea, Aline [3 ]
Namer, Izzie Jacques [1 ,4 ,5 ]
Imperiale, Alessio [1 ,4 ,5 ]
机构：
[1] Univ Hosp Strasbourg, Dept Biophys & Nucl Med, Strasbourg, France
[2] Univ Hosp Strasbourg, Dept Otolaryngol & Maxillofacial Surg, Strasbourg, France
[3] Univ Hosp Strasbourg, Dept Pathol, Strasbourg, France
[4] Univ Strasbourg, CNRS, UMR 7357, ICube, Strasbourg, France
[5] FMTS, Fac Med, Strasbourg, France
来源：
CLINICAL NUCLEAR MEDICINE | 2015年 / 40卷 / 07期
关键词：
IN-VITRO; 3-O-METHYL-6-F-18-FLUORO-L-DOPA; TRANSPORT;
D O I：
10.1097/RLU.0000000000000818
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
We report the unexpected findings of F-18-fluorodihydroxyphenylalanine (F-18-FDOPA) PET/CT performed in a patient with a history of ileal carcinoid. A focally increased F-18-FDOPA uptake was detected in the left side of the epiglottis corresponding to a laryngeal squamous cell carcinoma. Interestingly, uptake of 3-O-methyl-6-F-18-fluoro-l-dihydroxyphenylalanine, a metabolite of F-18-FDOPA, has been previously reported in both squamous cell carcinoma cell lines and the corresponding mouse tumor xenograft models. Although F-18-FDOPA is mainly used in patients with neuroendocrine tumors, F-18-FDOPA is not a neuroendocrine tumor-specific radiotracer.
引用
收藏
页码：e370 / e371
页数：2
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