TBHP/I2-promoted oxidative coupling of acetophenones with amines at room temperature under metal-free and solvent-free conditions for the synthesis of α-ketoamides

被引：173
|
作者：
Zhang, Xiaobin [1 ]
Wang, Lei [1 ,2 ]
机构：
[1] Huaibei Normal Univ, Dept Chem, Huaibei 235000, Anhui, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China
来源：
GREEN CHEMISTRY | 2012年 / 14卷 / 08期
基金：
美国国家科学基金会;
关键词：
ONE-POT SYNTHESIS; C-H ACTIVATION; DOUBLE CARBONYLATION; ARYL IODIDES; KETO AMIDE; INTRAMOLECULAR CYCLIZATION; CYCLOTHEONAMIDE-B; INHIBITORS; DERIVATIVES; IODINE;
D O I：
10.1039/c2gc35489f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel and efficient TBHP/I-2-promoted oxidative coupling reaction of acetophenones with amines for the synthesis of alpha-ketoamides has been developed. The reactions proceeded smoothly at room temperature under metal-free and solvent-free conditions and generated the corresponding products in good yields.
引用
收藏
页码：2141 / 2145
页数：5
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