IL-36 A NEW MEMBER OF THE IL-1 FAMILY CYTOKINES

被引：2
|
作者：
Tripodi, D. [1 ]
Conti, F. [2 ]
Rosati, M. [2 ]
Maccauro, G. [3 ]
Saggini, A. [4 ]
Cianchetti, E.
Angelucci, D. [5 ]
Fulcheri, M. [6 ]
Tete, S. [1 ]
Salini, V. [7 ]
Caraffa, A. [8 ]
Antinolfi, P. [8 ]
Toniato, E. [9 ]
Castellani, M. L. [9 ]
Conti, P. [9 ]
Theoharides, T. C. [10 ]
机构：
[1] Univ G dAnnunzio, Sch Dent, Pescara, Italy
[2] Osped Pescara, Gynecol Div, Pescara, Italy
[3] Univ Cattolica Sacro Cuore, Dept Orthoped, Rome, Italy
[4] Univ Roma Tor Vergata, Dept Dermatol, Rome, Italy
[5] Chieti Hosp, Chieti, Italy
[6] Univ G dAnnunzio, Dept Psychol, Chieti, Italy
[7] Univ G dAnnunzio, Dept Orthoped, Chieti, Italy
[8] Univ Perugia, Dept Orthoped, I-06100 Perugia, Italy
[9] Univ G dAnnunzio, Immunol Div, Pescara, Italy
[10] Tufts Univ, Sch Med, New England Med Ctr, Dept Physiol & Pharmacol, Boston, MA 02111 USA
来源：
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS | 2012年 / 26卷 / 01期
关键词：
IL-36; cytokines; interleukins; inflammation; immunity; BLOOD MONONUCLEAR-CELLS; NECROSIS-FACTOR-ALPHA; IN-VITRO; KAPPA-B; RHEUMATOID-ARTHRITIS; MESSENGER-RNA; EXPRESSION; INTERLEUKIN-1; CHILDREN; COMBINATION;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Interleukin-36 (IL-36) is a pro-inflammatory cytokine which plays an important role in innate and adaptive immunity. IL-36 activates MAPK and NF-KB pathways and is produced by many different cells. This cytokine is a family member of interleukin-1 (IL-1) and plays an important role in the pathophysiology of several diseases. Here we summarise and review the new aspects of this important pro-inflammatory cytokine.
引用
收藏
页码：7 / 14
页数：8
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