IL-36 A NEW MEMBER OF THE IL-1 FAMILY CYTOKINES

被引：2

作者：

Tripodi, D. ^{[1
]}

Conti, F. ^{[2
]}

Rosati, M. ^{[2
]}

Maccauro, G. ^{[3
]}

Saggini, A. ^{[4
]}

Cianchetti, E.

Angelucci, D. ^{[5
]}

Fulcheri, M. ^{[6
]}

Tete, S. ^{[1
]}

Salini, V. ^{[7
]}

Caraffa, A. ^{[8
]}

Antinolfi, P. ^{[8
]}

Toniato, E. ^{[9
]}

Castellani, M. L. ^{[9
]}

Conti, P. ^{[9
]}

Theoharides, T. C. ^{[10
]}

机构：

[1] Univ G dAnnunzio, Sch Dent, Pescara, Italy

[2] Osped Pescara, Gynecol Div, Pescara, Italy

[3] Univ Cattolica Sacro Cuore, Dept Orthoped, Rome, Italy

[4] Univ Roma Tor Vergata, Dept Dermatol, Rome, Italy

[5] Chieti Hosp, Chieti, Italy

[6] Univ G dAnnunzio, Dept Psychol, Chieti, Italy

[7] Univ G dAnnunzio, Dept Orthoped, Chieti, Italy

[8] Univ Perugia, Dept Orthoped, I-06100 Perugia, Italy

[9] Univ G dAnnunzio, Immunol Div, Pescara, Italy

[10] Tufts Univ, Sch Med, New England Med Ctr, Dept Physiol & Pharmacol, Boston, MA 02111 USA

来源：

JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS | 2012年 / 26卷 / 01期

关键词：

IL-36; cytokines; interleukins; inflammation; immunity; BLOOD MONONUCLEAR-CELLS; NECROSIS-FACTOR-ALPHA; IN-VITRO; KAPPA-B; RHEUMATOID-ARTHRITIS; MESSENGER-RNA; EXPRESSION; INTERLEUKIN-1; CHILDREN; COMBINATION;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interleukin-36 (IL-36) is a pro-inflammatory cytokine which plays an important role in innate and adaptive immunity. IL-36 activates MAPK and NF-KB pathways and is produced by many different cells. This cytokine is a family member of interleukin-1 (IL-1) and plays an important role in the pathophysiology of several diseases. Here we summarise and review the new aspects of this important pro-inflammatory cytokine.

引用

页码：7 / 14

页数：8

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