Synthesis of axially chiral N-aryl benzimidazoles via chiral phosphoric acid catalyzed enantioselective oxidative aromatization

被引：3

作者：

Chen, Jin-fang ^{[1
]}

Shi, Jin-yi ^{[1
]}

Yin, Cong-cong ^{[1
]}

Cui, Xin ^{[2
]}

Li, Guang-xun ^{[2
]}

Tang, Zhuo ^{[2
]}

Zhao, Jin-zhong ^{[1
]}

机构：

[1] Shanxi Agr Univ, Coll Art & Sci, Taigu 030800, Shanxi, Peoples R China

[2] Chinese Acad Sci, Nat Prod Res Ctr, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China

来源：

NEW JOURNAL OF CHEMISTRY | 2022年 / 46卷 / 14期

基金：

中国科学院西部之光基金;

关键词：

TRANSFER HYDROGENATION; BRONSTED ACID; ATROPISOMERS; CONSTRUCTION; COMPLEXES; HYDRIDE;

D O I：

10.1039/d1nj06092a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Given the great importance of N-substituted benzimidazoles in pharmaceutics, here N-aryl benzimidazoline produced in situ was used as a H-2 donor, which was converted to C-N axially chiral N-aryl benzimidazole by CPA-catalyzed enantioselective transfer hydrogenation of the in situ produced imine.

引用

页码：6398 / 6402

页数：5

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