Synthesis of (Hetero)arylated Pyridazin-3(2H)-ones via Negishi Reaction Involving Zincated Pyridazin-3(2H)-ones

被引：0

作者：

Verhelst, Tom ^{[1
]}

Liu, Zuming ^{[1
]}

Maes, Jens ^{[1
]}

Maes, Bert U. W. ^{[1
]}

机构：

[1] Univ Antwerp, Dept Chem, B-2020 Antwerp, Belgium

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 23期

关键词：

DERIVATIVES; PD; COMPLEXES; AROMATICS; EFFICIENT; HALIDES; SYSTEMS; DESIGN;

D O I：

10.1021/jo201587J

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Zincated pyridazin-3(2H)-ones generated via bromine magnesium exchange followed by transmetalation using ZnCl2 or via lactam-directed ortho C4-H zincation with TMPZnCl center dot LiCl have been synthesized. These in situ created organometalfics can be used in Negishi reactions with iodo(hetero)arenes delivering a new approach toward (hetero)arylpyridazin-3(2H)-ones.

引用

页码：9648 / 9659

页数：12

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