Synthesis of (Hetero)arylated Pyridazin-3(2H)-ones via Negishi Reaction Involving Zincated Pyridazin-3(2H)-ones

被引：0
|
作者：
Verhelst, Tom [1 ]
Liu, Zuming [1 ]
Maes, Jens [1 ]
Maes, Bert U. W. [1 ]
机构：
[1] Univ Antwerp, Dept Chem, B-2020 Antwerp, Belgium
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 23期
关键词：
DERIVATIVES; PD; COMPLEXES; AROMATICS; EFFICIENT; HALIDES; SYSTEMS; DESIGN;
D O I：
10.1021/jo201587J
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Zincated pyridazin-3(2H)-ones generated via bromine magnesium exchange followed by transmetalation using ZnCl2 or via lactam-directed ortho C4-H zincation with TMPZnCl center dot LiCl have been synthesized. These in situ created organometalfics can be used in Negishi reactions with iodo(hetero)arenes delivering a new approach toward (hetero)arylpyridazin-3(2H)-ones.
引用
收藏
页码：9648 / 9659
页数：12
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