transcranial magnetic stimulation;
amyotrophic lateral sclerosis;
triple stimulation technique;
D O I:
10.1016/j.clinph.2003.10.003
中图分类号:
R74 [神经病学与精神病学];
学科分类号:
摘要:
Objective: The authors studied amyotrophic lateral sclerosis (ALS) patients using triple stimulation technique (TST) to detect upper motor neuron (UMN) involvement. Methods: Nineteen ALS patients (aged 45-72 years) were enrolled in the study. According to the El Escorial criteria, 6 diagnoses were suspected or possible, 6 probable, and 7 definite. Patients were examined clinically, with conventional (single-pulse) transcranial magnetic stimulation (TMS), and with TST (on one side only). Results: Among the whole group of patients, TST appeared to be more sensitive than conventional TMS techniques. In particular among suspected/possible ALS patients, TST area ratio was pathologic in 100%, while single-pulse TMS was abnormal only in 50% of cases. Overall, the use of TST area ratio was more sensitive than the analysis of TST amplitude ratio. Conclusions: The results suggest that TST might be more sensitive and useful in the diagnosis of subclinical UMN involvement than conventional TMS techniques, even if TST is performed on one side only. (C) 2003 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
机构:
Virginia Commonwealth Univ Hlth Syst, Dept Orthopaed Surg, Div Hand Surg, Richmond, VA 23284 USAVirginia Commonwealth Univ Hlth Syst, Dept Orthopaed Surg, Div Hand Surg, Richmond, VA 23284 USA
Adams, Scott
论文数: 引用数:
h-index:
机构:
Isaacs, Jonathan
JOURNAL OF HAND SURGERY-AMERICAN VOLUME,
2010,
35A
(05):
: 844
-
845
机构:
Neurosci Res Australia, Sydney, NSW 2031, Australia
Univ New S Wales, Prince Wales Clin Sch, Sydney, NSW, AustraliaNeurosci Res Australia, Sydney, NSW 2031, Australia
Kiernan, Matthew C.
Vucic, Steve
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sydney, Western Clin Sch, Sydney, NSW 2006, AustraliaNeurosci Res Australia, Sydney, NSW 2031, Australia
Vucic, Steve
Cheah, Benjamin C.
论文数: 0引用数: 0
h-index: 0
机构:
Neurosci Res Australia, Sydney, NSW 2031, Australia
Univ New S Wales, Prince Wales Clin Sch, Sydney, NSW, AustraliaNeurosci Res Australia, Sydney, NSW 2031, Australia
Cheah, Benjamin C.
Turner, Martin R.
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h-index: 0
机构:
Univ Oxford, Nuffield Dept Clin Neurosci, Oxford, EnglandNeurosci Res Australia, Sydney, NSW 2031, Australia
Turner, Martin R.
Eisen, Andrew
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h-index: 0
机构:
Univ British Columbia, Dept Med, Div Neurol, Vancouver, BC V6T 1W5, CanadaNeurosci Res Australia, Sydney, NSW 2031, Australia
Eisen, Andrew
Hardiman, Orla
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h-index: 0
机构:
Trinity Coll Dublin, Inst Neurosci, Dublin, IrelandNeurosci Res Australia, Sydney, NSW 2031, Australia
Hardiman, Orla
Burrell, James R.
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h-index: 0
机构:
Neurosci Res Australia, Sydney, NSW 2031, Australia
Univ New S Wales, Prince Wales Clin Sch, Sydney, NSW, AustraliaNeurosci Res Australia, Sydney, NSW 2031, Australia
Burrell, James R.
Zoing, Margaret C.
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机构:
Neurosci Res Australia, Sydney, NSW 2031, Australia
Univ New S Wales, Prince Wales Clin Sch, Sydney, NSW, AustraliaNeurosci Res Australia, Sydney, NSW 2031, Australia
机构:
Royal Preston Hosp, Motor Neurone Dis Care & Res Ctr, Preston PR2 9HT, Lancs, EnglandRoyal Preston Hosp, Motor Neurone Dis Care & Res Ctr, Preston PR2 9HT, Lancs, England
Mitchell, J. D.
Borasio, G. D.
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机构:Royal Preston Hosp, Motor Neurone Dis Care & Res Ctr, Preston PR2 9HT, Lancs, England