Two new 7, 20-epoxy-ent-kauranes from the aerial parts of Isodon eriocalyx

被引：2
|
作者：
Li, Shu-Ying [1 ]
Zhu, Li-Hua [1 ,3 ]
Rao, Zheng-Yun [2 ]
Wang, Chao-Jun [2 ]
Jiang, Min [2 ]
Zhang, Jian [3 ]
Yin, Zhi-Qi [1 ]
机构：
[1] China Pharmaceut Univ, Sch Tradit Chinese Med, Dept TCMs Pharmaceut, Nanjing, Peoples R China
[2] Hongyun Pharmaceut Co Ltd, Inst Drug Discovery, Chengdu, Peoples R China
[3] Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Weste, Lab Translat Med, Nanjing, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 21期
关键词：
Isodon eriocalyx; 7,20-epoxy-ent-kaurane; anti-inflammatory activity; interleukin-1; beta; ENT-KAURANE DITERPENOIDS;
D O I：
10.1080/14786419.2020.1744141
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Two previously undescribed 7, 20-epoxy-ent-kauranes along with six known ent-kauranoids, were isolated from the aerial parts of Isodon eriocalyx. The structures of new compounds were established on the basis of extensive spectroscopic analyses. Compound 2 could inhibit the production of interleukin - 1 beta (IL - 1 beta) in monosodium urate (MSU) and lipopolysaccharide (LPS) induced macrophages. [GRAPHICS] .
引用
收藏
页码：3859 / 3864
页数：6
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