Polymer-supported synthesis of α- and β-hydroxyketones through the Formation of 1,3-dithiane intermediates

被引：3
|
作者：
Bertini, Vincenzo [1 ]
Lucchesini, Francesco [1 ]
Pocci, Marco [1 ]
Alfei, Silvana [1 ]
Idini, Barbara [1 ]
机构：
[1] Univ Genoa, Dipartimento Chim & Tecnol Farmaceut Alimentari, I-16147 Genoa, Italy
来源：
SYNLETT | 2008年 / 08期
关键词：
solid-phase synthesis; polymeric dithiols; polymeric dithianes; lithiation; umpolung;
D O I：
10.1055/s-2008-1072738
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of polymer-supported 2-monosubstituted 1,3-dithianes from soluble copolymers bearing 1,3-propanedithiol groups, their lithiation, reactions with electrophiles such as aldehydes, ketones, alpha,beta-unsaturated ketones and oxiranes, and cleavage of the produced dithioketal-protected alpha- or beta-hydroxyketones with various reagents have been studied.
引用
收藏
页码：1141 / 1144
页数：4
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