Polymer-supported synthesis of α- and β-hydroxyketones through the Formation of 1,3-dithiane intermediates

被引：3

作者：

Bertini, Vincenzo ^{[1
]}

Lucchesini, Francesco ^{[1
]}

Pocci, Marco ^{[1
]}

Alfei, Silvana ^{[1
]}

Idini, Barbara ^{[1
]}

机构：

[1] Univ Genoa, Dipartimento Chim & Tecnol Farmaceut Alimentari, I-16147 Genoa, Italy

来源：

SYNLETT | 2008年 / 08期

关键词：

solid-phase synthesis; polymeric dithiols; polymeric dithianes; lithiation; umpolung;

D O I：

10.1055/s-2008-1072738

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of polymer-supported 2-monosubstituted 1,3-dithianes from soluble copolymers bearing 1,3-propanedithiol groups, their lithiation, reactions with electrophiles such as aldehydes, ketones, alpha,beta-unsaturated ketones and oxiranes, and cleavage of the produced dithioketal-protected alpha- or beta-hydroxyketones with various reagents have been studied.

引用

页码：1141 / 1144

页数：4

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