Utilizing the CF2H moiety as a H-bond-donating group in drug discovery

被引：71
|
作者：
Zafrani, Yossi [1 ]
Saphier, Sigal [1 ]
Gershonov, Eytan [1 ]
机构：
[1] Israel Inst Biol Res, Dept Organ Chem, IL-74100 Ness Ziona, Israel
来源：
FUTURE MEDICINAL CHEMISTRY | 2020年 / 12卷 / 05期
关键词：
bioisostere; difluoromethyl; drug design; hydrogen bond; POTENT INHIBITORS; DESIGN; FLUORINE;
D O I：
10.4155/fmc-2019-0309
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：361 / 366
页数：6
相关论文
共 50 条
  • [11] Progress in development of methods for the incorporation of -CF2H or -CF2- groups into organic molecules
    Dolbier, William R.
    Thomoson, Charles S.
    Okamoto, Masamune
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248
  • [12] Difluoromethyl phenoxathiinium salt: A new general and versatile difluoromethylating reagent with divergent ·CF2H, CF2H+, and:CF2 reactivities
    Yuan-Qing Gu
    Hong-Xin Long
    Dan-Dan Zhang
    Mei-Feng Ruan
    Guo-Kai Liu
    Science China Chemistry, 2024, 67 : 953 - 962
  • [13] Difluoromethyl phenoxathiinium salt: A new general and versatile difluoromethylating reagent with divergent ·CF2H, CF2H+, and :CF2 reactivities
    Yuan-Qing Gu
    Hong-Xin Long
    Dan-Dan Zhang
    Mei-Feng Ruan
    Guo-Kai Liu
    Science China(Chemistry) , 2024, (03) : 953 - 962
  • [14] Nucleophilic Difluoromethylation of Epoxides with PhSO(NTBS)CF2H by a Preorganization Strategy
    Shen, Xiao
    Liu, Qinghe
    Luo, Tao
    Hu, Jinbo
    CHEMISTRY-A EUROPEAN JOURNAL, 2014, 20 (22) : 6795 - 6800
  • [15] CF2H, a Functional Group-Dependent Hydrogen-Bond Donor: Is It a More or Less Lipophilic Bioisostere of OH, SH, and CH3?
    Zafrani, Yossi
    Sod-Moriah, Gali
    Yeffet, Dina
    Berliner, Anat
    Amir, Dafna
    Marciano, Daniele
    Elias, Shlomi
    Katalan, Shahaf
    Ashkenazi, Nissan
    Madmon, Moran
    Gershonov, Eytan
    Saphier, Sigal
    JOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (11) : 5628 - 5637
  • [16] DISPROPORTIONATION REACTIONS BETWEEN CF2H AND C2H5 RADICALS IN THE GAS-PHASE
    NILSSON, WB
    PRITCHARD, GO
    INTERNATIONAL JOURNAL OF CHEMICAL KINETICS, 1982, 14 (03) : 299 - 323
  • [17] Difluoromethyl phenoxathiinium salt: A new general and versatile difluoromethylating reagent with divergent <middle dot>CF2H, CF2H+, and:CF2 reactivities
    Gu, Yuan-Qing
    Long, Hong-Xin
    Zhang, Dan-Dan
    Ruan, Mei-Feng
    Liu, Guo-Kai
    SCIENCE CHINA-CHEMISTRY, 2024, 67 (03) : 953 - 962
  • [18] Copper-Mediated -CF(OCF3)(CF2H) Transfer to Organic Electrophiles
    Ghaffari, Behnaz
    Porto, Luana L. T. N.
    Johnson, Nicole
    Ovens, Jeffrey S.
    Ehm, Christian
    Baker, R. Tom
    ACS ORGANIC & INORGANIC AU, 2024, 4 (06): : 628 - 639
  • [19] [(SIPr)Ag(CF2H)]: A Shelf-Stable, Versatile Difluoromethylation Reagent
    Zhao, Haiwei
    Gu, Yang
    Shen, Qilong
    CHEMICAL RECORD, 2023, 23 (09):
  • [20] The Difluoromethylated Organogold(III) Complex cis-[Au(PCy3)(4-F-C6H4)(CF2H)(CI)]: Preparation, Characterization, and Its C(sp2)-CF2H Reductive Elimination
    Liu, Shuanshuan
    Kang, Kai
    Liu, Shihan
    Wang, Decai
    Wei, Ping
    Lan, Yu
    Shen, Qilong
    ORGANOMETALLICS, 2018, 37 (21) : 3901 - 3908
12345