Selective Cross-Dehydrogenative C(sp3)-H Arylation with Arenes

被引：22
|
作者：
Hao, Hong-Yan [1 ]
Mao, Yang-Jie [1 ]
Xu, Zhen-Yuan [1 ]
Lou, Shao-Jie [1 ]
Xu, Dan-Qian [1 ]
机构：
[1] Zhejiang Univ Technol, Catalyt Hydrogenat Res Ctr, State Key Lab Breeding Base Green Chem Synth Tech, Key Lab Green Pesticides & Cleaner Prod Technol Z, Hangzhou 310014, Peoples R China
来源：
ORGANIC LETTERS | 2020年 / 22卷 / 06期
基金：
中国博士后科学基金;
关键词：
C-H FUNCTIONALIZATION; BOND FUNCTIONALIZATION; SILYLATION; C(SP(2))-H; CHEMISTRY;
D O I：
10.1021/acs.orglett.0c00588
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Selective C(sp(3))-C(sp(2)) bond construction is of central interest in chemical synthesis. Despite the success of classic cross-coupling reactions, the cross-dehydrogenative coupling between inert C(sp(3))-H and C(sp(2))-H bonds represents an attractive alternative toward new C(sp(3))-C(sp(2)) bonds. Herein, we establish a selective inter- and intramolecular C(sp(3))-H arylation of alcohols with nondirected arenes that thereby provides a general pathway to access a wide range of beta-arylated alcohols, including tetrahydronaphthalen-2-ols and benzopyran-3-ols, with high to excellent chemo- and regioselectivity.
引用
收藏
页码：2396 / 2402
页数：7
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