Prospective on using fibre mid-infrared supercontinuum laser sources for in vivo spectral discrimination of disease

被引：39

作者：

Seddon, Angela B. ^{[1
]}

Napier, Bruce ^{[2
]}

Lindsay, Ian ^{[3
,4
]}

Lamrini, Samir ^{[5
]}

Moselund, Peter M. ^{[6
]}

Stone, Nicholas ^{[7
]}

Bang, Ole ^{[8
]}

Farries, Mark ^{[9
]}

机构：

[1] Univ Nottingham, Fac Engn, George Green Inst Electromagnet Res, Midinfrared Photon Grp, Nottingham NG7 2RD, England

[2] Vivid Components Ltd, German Off, Dr Rorig Damm 22, D-33102 Paderborn, Germany

[3] Gooch & Housego, Ilminster, England

[4] Univ Bristol, HH Wills Phys Lab, Tyndall Ave, Bristol BS8 1TL, Avon, England

[5] LISA Laser Prod OHG, Fuhrberg & Teichmann, Albert Einstein Str 1-9, D-37191 Katlenburg Lindau, Germany

[6] NKT Photon AS, Blokken 84, DK-3460 Birkerod, Denmark

[7] Univ Exeter, Coll Engn Math & Phys Sci, Phys & Astron, Exeter EX4 4QL, Devon, England

[8] Tech Univ Denmark, DTU Fotonik, Fibre Sensors & Supercontinuum Grp, DK-2800 Lyngby, Denmark

[9] Gooch & Housego Torquay, Broomhill Way, Torquay TQ2 7QL, England

来源：

ANALYST | 2018年 / 143卷 / 24期

基金：

英国工程与自然科学研究理事会;

关键词：

INFRARED-SPECTROSCOPY; CHALCOGENIDE GLASSES; IR;

D O I：

10.1039/c8an01396a

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Mid-infrared (MIR) fibre-optics may play a future role in in vivo diagnosis of disease, including cancer. Recently, we reported for the first time an optical fibre based broadband supercontinuum (SC) laser source spanning 1.3 to 13.4 m wavelength to cover the spectral fingerprint region' of biological tissue. This work has catalysed the new field of fibre MIR-SC and now very bright sources equivalent to a few synchrotrons' have been demonstrated in fibre. In addition, we have made record transparency MIR fibre for routeing the MIR light and reported first-time MIR photoluminescence (with long lifetime) in small-core, rare earth ion doped, MIR fibre - an important step towards MIR fibre lasing at >4 m wavelength for pumping fibre MIR-SC. First time fibre MIR-SC spectroscopic imaging of colon tissue is described at wavelengths in the fingerprint region'.

引用

页码：5874 / 5887

页数：14

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