Do mitochondria have an immune system?

被引：5

作者：

Popkov, V. A. ^{[1
,2
]}

Zorova, L. D. ^{[3
]}

Korvigo, I. O. ^{[4
]}

Silachev, D. N. ^{[1
]}

Jankauskas, S. S. ^{[1
]}

Babenko, V. A. ^{[1
,2
]}

Pevzner, I. B. ^{[1
]}

Danilina, T. I. ^{[2
]}

Zorov, S. D. ^{[2
]}

Plotnikov, E. Y. ^{[1
]}

Zorov, D. B. ^{[1
]}

机构：

[1] Lomonosov Moscow State Univ, Belozersky Inst Physicochem Biol, Moscow 119991, Russia

[2] Lomonosov Moscow State Univ, Fac Bioengn & Bioinformat, Moscow 119991, Russia

[3] Lomonosov Moscow State Univ, Int Laser Res Ctr, Moscow 119991, Russia

[4] Moscow Inst Phys & Technol, Dolgoprudnyi 141701, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2016年 / 81卷 / 10期

基金：

俄罗斯科学基金会;

关键词：

mitochondria; immune system; virus; VIRUS X-PROTEIN; ANTIVIRAL SIGNALING PROTEIN; PERMEABILITY TRANSITION PORE; HEPATITIS-C; OXIDATIVE STRESS; INNATE IMMUNITY; MEMBRANE PERMEABILIZATION; ELECTRON-MICROSCOPE; PREVENTS APOPTOSIS; CALCIUM-UPTAKE;

D O I：

10.1134/S0006297916100217

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The question if mitochondria have some kind of immune system is not trivial. The basis for raising this question is the fact that bacteria, which are progenitors of mitochondria, do have an immune system. The CRISPR system in bacteria based on the principle of RNA interference serves as an organized mechanism for destroying alien nucleic acids, primarily those of viral origin. We have shown that mitochondria are also a target for viral attacks, probably due to a related organization of genomes in these organelles and bacteria. Bioinformatic analysis performed in this study has not given a clear answer if there is a CRISPR-like immune system in mitochondria. However, this does not preclude the possibility of mitochondrial immunity that can be difficult to decipher or that is based on some principles other than those of CRISPR.

引用

页码：1229 / 1236

页数：8

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