A two-step synthesis of 1,5-disubstituted tetrazoles containing a siloxy or sulfonamide group

被引：8
|
作者：
Sarvary, Afshin [1 ]
Shaabani, Shabnam [1 ]
Shaabani, Ahmad [1 ]
Ng, SeikWeng [2 ]
机构：
[1] Shahid Beheshti Univ, Dept Chem, Tehran, Iran
[2] Univ Malaya, Dept Chem, Kuala Lumpur 50603, Malaysia
来源：
TETRAHEDRON LETTERS | 2011年 / 52卷 / 45期
关键词：
1,5-Disubstituted tetrazole; Ketenimine; Isocyanide; Multicomponent; SOLUTION-PHASE PREPARATION; ONE-POT; EFFICIENT SYNTHESIS; DERIVATIVES; ISOCYANIDES; ANTICANCER;
D O I：
10.1016/j.tetlet.2011.08.114
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple two-step route to the synthesis of 1,5-disubstituted tetrazoles containing a beta-siloxy or beta-sulfonamide group is presented. The synthesis takes place via an isocyanide-based multicomponent reaction and allows incorporation of a wide variety of substitution patterns starting from commercially available reagents. This is followed by cyclization of the ketenimines with trimethylsilyl azide without using any catalyst or activation. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5930 / 5933
页数：4
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