New insights on oxidative stress in the artery wall

被引:144
|
作者
Stocker, R [1 ]
Keaney, JF
机构
[1] Univ New S Wales, Sch Med Sci, Ctr Vasc Res, Sydney, NSW 2052, Australia
[2] Boston Univ, Med Ctr, Dept Med, Whitaker Cardiovasc Inst, Boston, MA USA
关键词
antioxidants; atherosclerosis; cardiovascular disease; inflammation; oxidative stress;
D O I
10.1111/j.1538-7836.2005.01370.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Atherosclerosis and its resultant cardiovascular events represent a state of heightened oxidative stress that is commonly thought to contribute to atherogenesis. The aim of this review is to summarize the data linking oxidative events to the pathogenesis of atherosclerosis. Despite abundant data supporting the presence of lipid and protein oxidation in the vascular wall, the poor performance of antioxidant strategies in limiting either atherosclerosis or cardiovascular events from atherosclerosis remain a fundamental problem for implicating oxidative stress as pathophysiologically important. Direct evidence that oxidative stress in general, and the oxidative modification of low-density lipoprotein in particular, is both necessary and sufficient for atherosclerosis has been difficult to find. There are many potential reasons for this difficulty, not the least of which is our lack of sufficient knowledge delineating the precise molecular events that beget oxidative stress in the vessel wall, and the precise mediators involved. Further investigation elucidating these oxidative events are required to provide us with the tools to limit oxidative stress at its source and ameliorate all of its secondary phenomena. Only then will we know what components of atherosclerosis are directly due to oxidative stress.
引用
收藏
页码:1825 / 1834
页数:10
相关论文
共 50 条
  • [21] The sources of oxidative stress in the vessel wall
    Wolin, MS
    Ahmad, M
    Gupte, SA
    KIDNEY INTERNATIONAL, 2005, 67 (05) : 1659 - 1661
  • [22] Some Current Insights into Oxidative Stress
    Durackova, Z.
    PHYSIOLOGICAL RESEARCH, 2010, 59 (04) : 459 - 469
  • [23] Insights into the respiratory chain and oxidative stress
    Larosa, Veronique
    Remacle, Claire
    BIOSCIENCE REPORTS, 2018, 38
  • [24] Oxidative stress is the new stress
    Jay A Gingrich
    Nature Medicine, 2005, 11 : 1281 - 1282
  • [25] Oxidative stress is the new stress
    Gingrich, JA
    NATURE MEDICINE, 2005, 11 (12) : 1281 - 1282
  • [26] Oxidative stress:New insights on the association of nonalcoholic fatty liver disease and atherosclerosis
    Licia Polimeni
    Maria Del Ben
    Francesco Baratta
    Ludovica Perri
    Fabiana Albanese
    Daniele Pastori
    Francesco Violi
    Francesco Angelico
    World Journal of Hepatology, 2015, 7 (10) : 1325 - 1336
  • [27] Oxidative stress and inflammation regulation of sirtuins: New insights into common oral diseases
    Pan, Zijian
    Dong, Hao
    Huang, Ning
    Fang, Jie
    FRONTIERS IN PHYSIOLOGY, 2022, 13
  • [28] Oxidative Stress in Intervertebral Disc Degeneration: New Insights from Bioinformatic Strategies
    Zhao, Yongzhao
    Xiang, Qian
    Lin, Jialiang
    Jiang, Shuai
    Li, Weishi
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2022, 2022
  • [29] New insights into how adenovirus might lead to obesity: An oxidative stress theory
    Waye, Mary Miu Yee
    FREE RADICAL RESEARCH, 2011, 45 (08) : 880 - 887
  • [30] New Insights on Dietary Polyphenols for the Management of Oxidative Stress and Neuroinflammation in Diabetic Retinopathy
    Fanaro, Gustavo Bernardes
    Marques, Marcelo Rodrigues
    Calaza, Karin da Costa
    Brito, Rafael
    Pessoni, Andre Moreira
    Mendonca, Henrique Rocha
    Lemos, Deborah Emanuelle de Albuquerque
    de Brito Alves, Jose Luiz
    de Souza, Evandro Leite
    Cavalcanti Neto, Marinaldo Pacifico
    ANTIOXIDANTS, 2023, 12 (06)