Recommendations for Advancing the Diagnosis and Management of Hereditary Breast and Ovarian Cancer in Brazil

被引:23
|
作者
Achatz, Maria Isabel [1 ]
Caleffi, Maira [2 ,3 ]
Guindalini, Rodrigo [4 ,5 ]
Marques, Renato Moretti [6 ,7 ]
Nogueira-Rodrigues, Angelica [8 ,9 ,10 ]
Ashton-Prolla, Patricia [11 ,12 ]
机构
[1] Hosp Sirio Libanes, Ctr Oncol, Sao Paulo, Brazil
[2] Nucleo Mama Porto Alegre, Porto Alegre, RS, Brazil
[3] Assoc Hosp Moinhos de Vento, Porto Alegre, RS, Brazil
[4] Rede DOr Sao Luiz, Oncol DOr, Rio De Janeiro, Brazil
[5] Univ Sao Paulo, Ctr Invest Translac Oncol, Inst Canc Estado Sao Paulo, Hosp Clin,Fac Med, Sao Paulo, Brazil
[6] Hosp Israelita Albert Einstein, Programa Saude Mulher, Sao Paulo, Brazil
[7] Hosp Israelita Albert Einstein, Ctr Oncol & Hematol, Sao Paulo, Brazil
[8] Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil
[9] Grp Brasileiro Oncol Ginecol, Belo Horizonte, MG, Brazil
[10] DOM Oncol, Divinopolis, MG, Brazil
[11] Univ Fed Rio Grande do Sul, Dept Genet, Porto Alegre, RS, Brazil
[12] Hosp Clin Porto Alegre, Lab Med Genom, Porto Alegre, RS, Brazil
关键词
BRCA MUTATION CARRIERS; NIPPLE-SPARING MASTECTOMY; COST-EFFECTIVENESS; HIGH-RISK; CONTRALATERAL MASTECTOMY; MAINTENANCE THERAPY; WOMEN; PANEL; TP53; SURVIVAL;
D O I
10.1200/JGO.19.00170
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
PURPOSEThe objective of this review was to address the barriers limiting access to genetic cancer risk assessment and genetic testing for individuals with suspected hereditary breast and ovarian cancer (HBOC) through a review of the diagnosis and management steps of HBOC.METHODSA selected panel of Brazilian experts in fields related to HBOC was provided with a series of relevant questions to address before the multiday conference. During this conference, each narrative was discussed and edited by the entire group, through numerous drafts and rounds of discussion, until a consensus was achieved.RESULTSThe authors propose specific and realistic recommendations for improving access to early diagnosis, risk management, and cancer care of HBOC specific to Brazil. Moreover, in creating these recommendations, the authors strived to address all the barriers and impediments mentioned in this article.CONCLUSIONThere is a great need to expand hereditary cancer testing and counseling in Brazil, and changing current policies is essential to accomplishing this goal. Increased knowledge and awareness, together with regulatory actions to increase access to this technology, have the potential to improve patient care and prevention and treatment efforts for patients with cancer across the country. (c) 2020 by American Society of Clinical Oncology
引用
收藏
页码:439 / 452
页数:14
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