Decrease in NF-κB, AP-I and SP-I activities in neuronal cells expressing presenilin 2

被引：7
|
作者：
Nguyen, HN
Lee, SY
Hwang, DY
Kim, YK
Yuk, DY
Lee, JS
Hong, JT [1 ]
机构：
[1] Chungbuk Natl Univ, Coll Pharm, Cheongju, South Korea
[2] Chungbuk Natl Univ Hosp, Cheongju 361763, Chungbuk, South Korea
[3] Korea Food & Dug Adm, Natl Inst Toxicol Res, Seoul 122704, South Korea
来源：
NEUROREPORT | 2005年 / 16卷 / 07期
关键词：
AP-I; neuronal cells; NF-kappa B; presenilin; 2; SP-I;
D O I：
10.1097/00001756-200505120-00015
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Decreases in activities of the NF-kappa B, AP-1 and SP-1 transcription factors, which could act as antiapoptotic factors, in the presenilin 2 transfected PC12 cells, either in nontreatment conditions or under apoptotic stimulation, were found in this study. Similar results were also found in mice brain cells carrying presenilin 2, especially in the mutant gene expressed ones. These findings suggested that presenilin 2 may be implicated in neuronal cell death by altering the antiapoptotic activity of the transcription factors. NeuroReport 16:731-735 (c) 2005 Lippincott Williams & Wilkins.
引用
收藏
页码：731 / 735
页数：5
相关论文
共 50 条
  • [31] Interaction of NF-κB and IκBα, IκBαM, IκBα243N or IκBα244C studied with fluorescent fusion proteins by FRET in living cells
    Li, Xian
    Chen, Xiaojia
    Tang, Yonghong
    FOURTH INTERNATIONAL CONFERENCE ON PHOTONICS AND IMAGING IN BIOLOGY AND MEDICINE, PTS 1 AND 2, 2006, 6047
  • [32] Fas ligation induces NF-κB activation in HT-29 cells by phosphorylation of IκBα through a process dependent on NF-κB inducing kinase (NIK) and IκB kinase β (IKKβ) and not through caspase dependent degradation of IκBα
    Russo, M
    Jobin, C
    GASTROENTEROLOGY, 2002, 122 (04) : A542 - A542
  • [33] Resveratrol inhibits NF-κB signaling through suppression of p65 and IκB kinase activities
    Ren, Zhenghua
    Wang, Lei
    Cui, Jianhua
    Huoc, Zeren
    Xue, Jinru
    Cui, Hao
    Mao, Qiqi
    Yang, Rirong
    PHARMAZIE, 2013, 68 (08): : 689 - 694
  • [34] Iκκ mediates NF-κB activation in human immunodeficiency virus-infected cells
    Asin, S
    Taylor, JA
    Trushin, S
    Bren, G
    Paya, CV
    JOURNAL OF VIROLOGY, 1999, 73 (05) : 3893 - 3903
  • [35] A20-binding Inhibitor of Nuclear Factor-κB (NF-κB)-2 (ABIN-2) Is an Activator of Inhibitor of NF-κB (IκB) Kinase α (IKKα)-mediated NF-κB Transcriptional Activity
    Leotoing, Laurent
    Chereau, Fanny
    Baron, Silvere
    Hube, Florent
    Valencia, Hugo J.
    Bordereaux, Didier
    Demmers, Jeroen A.
    Strouboulis, John
    Baud, Veronique
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (37) : 32277 - 32288
  • [36] Expression of AP-1, SP-1 and NF-κB during culture activation of hepatic stellate cells
    Mann, DA
    Elsharkawy, A
    Arthur, MPJ
    GUT, 1998, 43 (01) : 151 - 151
  • [37] LMP1 activates NF-κB via degradation of IκBα in nasopharyngeal carcinoma cells
    Yin, LQ
    Liao, W
    Deng, XY
    Tang, M
    Gu, HH
    Li, XY
    Yi, W
    Cao, Y
    CHINESE MEDICAL JOURNAL, 2001, 114 (07) : 718 - 722
  • [38] Alternative splicing variants of IκBβ establish differential NF-κB signal responsiveness in human cells
    Hirano, F
    Chung, MR
    Tanaka, H
    Maruyama, N
    Makino, I
    Moore, DD
    Scheidereit, C
    MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (05) : 2596 - 2607
  • [39] Aggregation of β2 integrins activates human neutrophils through the IκB/NF-κB pathway
    Kim, CH
    Lee, KH
    Lee, CT
    Kim, YW
    Han, SK
    Shim, YS
    Yoo, CG
    JOURNAL OF LEUKOCYTE BIOLOGY, 2004, 75 (02) : 286 - 292
  • [40] A switch in distinct IκBα degradation mechanisms mediates constitutive NF-κB activation in mature B cells
    Fields, ER
    Seufzer, BJ
    Oltz, EM
    Miyamoto, S
    JOURNAL OF IMMUNOLOGY, 2000, 164 (09): : 4762 - 4767
12345