An efficient total synthesis of (-)-anamarine

被引：7

作者：

Ramesh, Palakuri ^{[1
]}

Meshram, H. M. ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Organ Chem Div 1, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 31期

关键词：

Mannitol; (R)-Epichlorohydrin; Tosylation; Lactonization; Cross metathesis; Grubb's catalyst; STEREOSELECTIVE TOTAL-SYNTHESIS; HIV PROTEASE; INHIBITORS; APOPTOSIS; ALPHA; SPICIGEROLIDE; DEATH;

D O I：

10.1016/j.tetlet.2012.05.099

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of (-)-anamarine is described using D(+)-mannitol and (R)-epichlorohydrin. The synthesis is achieved starting from easily accessible D(+)-mannitol using a selective benzoylation, regioselective epoxide ring opening, a selective acetonide deprotection, tosylation and cross metathesis reaction. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：4008 / 4011

页数：4

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