An efficient total synthesis of (-)-anamarine

被引：7
|
作者：
Ramesh, Palakuri [1 ]
Meshram, H. M. [1 ]
机构：
[1] Indian Inst Chem Technol, Organ Chem Div 1, Hyderabad 500007, Andhra Pradesh, India
来源：
TETRAHEDRON LETTERS | 2012年 / 53卷 / 31期
关键词：
Mannitol; (R)-Epichlorohydrin; Tosylation; Lactonization; Cross metathesis; Grubb's catalyst; STEREOSELECTIVE TOTAL-SYNTHESIS; HIV PROTEASE; INHIBITORS; APOPTOSIS; ALPHA; SPICIGEROLIDE; DEATH;
D O I：
10.1016/j.tetlet.2012.05.099
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient synthesis of (-)-anamarine is described using D(+)-mannitol and (R)-epichlorohydrin. The synthesis is achieved starting from easily accessible D(+)-mannitol using a selective benzoylation, regioselective epoxide ring opening, a selective acetonide deprotection, tosylation and cross metathesis reaction. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4008 / 4011
页数：4
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