Blood Aluminum Levels in Patients with Hemodialysis and Peritoneal Dialysis

被引:6
|
作者
Chuang, Po-Hsun [1 ,2 ]
Tsai, Kai-Fan [2 ,3 ]
Wang, I-Kuan [4 ,5 ]
Huang, Ya-Ching [2 ,6 ]
Huang, Lan-Mei [1 ]
Liu, Shou-Hsuan [1 ,2 ]
Weng, Cheng-Hao [1 ,2 ]
Huang, Wen-Hung [1 ,2 ]
Hsu, Ching-Wei [1 ,2 ]
Lee, Wen-Chin [2 ,3 ]
Yen, Tzung-Hai [1 ,2 ]
机构
[1] Chang Gung Mem Hosp, Clin Poison Ctr, Dept Nephrol, Linkou 333, Taiwan
[2] Chang Gung Univ, Coll Med, Taoyuan 333, Taiwan
[3] Kaohsiung Chang Gung Mem Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 833, Taiwan
[4] China Med Univ Hosp, Dept Nephrol, Taichung 404, Taiwan
[5] China Med Univ, Coll Med, Taichung 406, Taiwan
[6] Chang Gung Mem Hosp, Dept Lab Med, Linkou 333, Taiwan
关键词
blood aluminum levels; hemodialysis; peritoneal dialysis; aluminum toxicity; CHRONIC KIDNEY-DISEASE; SERUM ALUMINUM; TOXICITY; HYPERALUMINEMIA; MORTALITY; STILL; TRACE;
D O I
10.3390/ijerph19073885
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Background. This retrospective observational study attempted to examine the prevalence of abnormal blood aluminum levels in dialysis patients, and to explore the association of pathogenic factors, such as demographic, clinical, laboratory as well as the use of phosphate binding drugs, drugs for secondary hyperparathyroidism and erythropoiesis-stimulating drugs with the blood aluminum levels. Methods. The study included 1175 patients (874 hemodialysis and 301 peritoneal dialysis), recruited from Chang Gung Memorial Hospital in November 2020. Patients were stratified into two groups by their blood aluminum levels, as normal (<2 mu g/dL, n = 1150) or abnormal (>= 2 mu g/dL, n = 25). Results. The patients aged 60.4 +/- 13.2 years and were dialyzed for 8.6 +/- 8.1 years. The average blood aluminum level was 1.0 +/- 0.4 mu g/dL. Patients with abnormal blood aluminum levels received more sevelamer than patients with normal blood aluminum level (p = 0.014). Patients with abnormal blood aluminum levels had higher platelet count (p = 0.001), triglyceride (p < 0.001) and total iron binding capacity (p = 0.003) than patients with normal blood aluminum levels. Moreover, the cardiothoracic ratio was higher in patients with abnormal blood aluminum levels than patients with normal blood aluminum levels (p = 0.003). Conclusions. The prevalence of abnormal blood aluminum levels was low at 2.2%. Nevertheless, the linking of cardiothoracic ratio of more than 0.5 as well as elevated blood platelet count and triglyceride level with blood aluminum levels are interesting, and warranted more researches in this area.
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页数:12
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