Preparation and Photosynthesis-Inhibiting Activity of 1-[(2-Nitrophenyl) carbamoyl] naphthalen-2-yl Alkylcarbamates

被引：0

作者：

Gonec, Tomas ^{[1
]}

Stranik, Josef ^{[1
]}

Pesko, Matus ^{[2
]}

Kos, Jiri ^{[1
]}

Oravec, Michal ^{[3
]}

Kralova, Katarina ^{[4
]}

Jampilek, Josef ^{[5
]}

机构：

[1] Univ Vet & Pharmaceut Sci, Fac Pharm, Dept Chem Drugs, Palackeho 1, Brno 61242, Czech Republic

[2] Comenius Univ, Fac Nat Sci, Dept Environm Ecol, Mlynska Dolina Ch 2, Bratislava 84215, Slovakia

[3] Global Change Res Inst CAS, Belidla 986-4a, Brno 60300, Czech Republic

[4] Comenius Univ, Fac Nat Sci, Inst Chem, Mlynska Dolina Ch 2, Bratislava 84215, Slovakia

[5] Comenius Univ, Fac Pharm, Dept Pharmaceut Chem, Odbojarov 10, Bratislava 83232, Slovakia

来源：

20TH INTERNATIONAL ELECTRONIC CONFERENCE ON SYNTHETIC ORGANIC CHEMISTRY (ECSOC) | 2016年

关键词：

Alkylcarbamates; Hydroxynaphthalene-carboxamides; PET inhibition; Spinach chloroplasts; Structure-activity relationships; BIOLOGICAL-ACTIVITY SPECTRUM; HERBICIDAL ACTIVITY; ELECTRON-TRANSPORT; SUBSTITUTED BENZANILIDES; ANTIBACTERIAL; SALICYLANILIDES; CHLOROPLASTS; UNCOUPLERS; ACIDS;

D O I：

10.3390/ecsoc-20-b004

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this study, a series of eight 1-[(2-nitrophenyl) carbamoyl] naphthalen-2-yl alkylcarbamates was prepared and characterized. The discussed compounds were prepared by microwave-assisted and conventional synthesis. The compounds were tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. The PET-inhibiting activity of the compounds was relatively low; the corresponding IC50 values ranged from 0.233 to 0.487 mmol/L and the highest activity within the series of compounds was observed for 1-[(2-nitrophenyl) carbamoyl] naphthalen-2-yl pentylcarbamate. The compounds were found to inhibit PET in photosystem II.

引用

页数：10

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